Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOVB3Y)

Drug Name
GKT-137831 Drug Info
Synonyms GKT-01; NADPH oxidase inhibitor (oral, renal cancer/ idiopathic pulmonary fibrosis), GenKyoTex
Indication
Disease Entry ICD 11 Status REF
Fibrosis GA14-GC01 Phase 2 [1]
Cross-matching ID
PubChem CID
58496428
CAS Number
CAS 1218942-37-0
TTD Drug ID
DMOVB3Y

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting NADPH oxidase (NOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
SINOMENINE DMYP3KI Arthritis FA20 Discontinued in Phase 2 [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
NADPH oxidase (NOX) TTFQVUT NOUNIPROTAC Modulator [2]
NADPH oxidase 4 (NOX4) TTQRBSJ NOX4_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT02010242) Safety and Efficacy of Oral GKT137831 in Patient With Type 2 Diabetes and Albuminuria. U.S. National Institutes of Health.
2 Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NOX) in Experimental Liver Fibrosis: GKT137831 as a Novel Potential Therapeutic Agent. Hepatology. 2012 December; 56(6): 2316-2327.
3 Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation. 2007 Sep 19;4:23.