Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOW07D)

Drug Name
BAP-15 Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Preclinical [1]
Cross-matching ID
TTD Drug ID
DMOW07D

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Ubiquitin carboxyl-terminal hydrolase 14 (USP14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID26077642-Compound-Figure3A DMENX90 N. A. N. A. Patented [3]
Tricyclic heterocycle derivative 4 DM9XBL4 N. A. N. A. Patented [3]
IU1 DMJ0A2R Neurodegenerative disorder 8A20-8A23 Preclinical [4]
Drug(s) Targeting Isopeptidase T (USP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
vialinin A DM95VQ6 Inflammation 1A00-CA43.1 Preclinical [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Isopeptidase T (USP5) TTGYTMA UBP5_HUMAN Inhibitor [2]
Ubiquitin carboxyl-terminal hydrolase 14 (USP14) TTVSYP9 UBP14_HUMAN Inhibitor [2]

References

1 Emerging therapies targeting the ubiquitin proteasome system in cancer. J Clin Invest. 2014 Jan;124(1):6-12.
2 The proteasome deubiquitinase inhibitor bAP15 downregulates TGF-/Smad signaling and induces apoptosis via UCHL5 inhibition in ovarian cancer. Oncotarget. 2019 Oct 15;10(57):5932-5948.
3 Deubiquitinases (DUBs) and DUB inhibitors: a patent review.Expert Opin Ther Pat. 2015;25(10):1191-1208.
4 Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1157-1170.
5 Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4328-31.