Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP6MH9)

• Drug Name: DA-8031 Drug Info
• Synonyms: Serotonin transporter inhibitor (premature ejaculation), Dong A

Indication

Disease Entry	ICD 11	Status	REF
Premature ejaculation	HA03.0Z	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 42606390
  TTD Drug ID: DMP6MH9

Molecule-Related Drug Atlas

Drug(s) Targeting Serotonin transporter (SERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[3]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[4]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[5]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[6]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[7]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[8]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[9]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[5]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[5]
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[5]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Serotonin transporter (SERT)	TT3ROYC	SC6A4_HUMAN	Inhibitor	[2]

References

• [1] ClinicalTrials.gov (NCT01798667) Clinical Trial to Evaluate the Efficacy and Safety of DA-8031 in Male Patients With Premature Ejaculation. U.S. National Institutes of Health.
• [2] Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior. Int J Urol. 2014 Mar;21(3):325-9.
• [3] Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice. Psychopharmacology (Berl). 2009 Sep;206(1):97-107.
• [4] Treatment of comorbid pain with serotonin norepinephrine reuptake inhibitors. CNS Spectr. 2008 Jul;13(7 Suppl 11):22-6.
• [5] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [6] Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
• [7] Psychopharmacological treatment of dermatological patients--when simply talking does not help. J Dtsch Dermatol Ges. 2007 Dec;5(12):1101-6.
• [8] Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. Pharmacol Biochem Behav. 2009 Jul;93(1):75-81.
• [9] Clinically relevant drug interactions with new generation antidepressants and antipsychotics. Ther Umsch. 2009 Jun;66(6):485-92.