Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMP9N85)

• Drug Name: Menadiol sodium diphosphate Drug Info
• Synonyms: Kappadione; Synkavit; Procoagulo; Synkavite; Thylokay; Kipca water soluble; Synkayvite; Menadiol sodium diphosphate; Menadione sodium phosphate; Sodium menadione diphosphate; Menadiol Sodium Diphosphate Anhydrous; UNII-R2L46WE615; Menadiol tetrasodium diphosphate; EINECS 205-012-1; Menadione diphosphate tetrasodium salt; 1:4-Naphthaquinol-bisdisodium phosphate; 131-13-5; Menadiol sodium diphosphate anhydrous [USAN]; R2L46WE615; 2-Methyl-1,4-naphthaquinol bis(disodium phosphate); Tetrasodium 2-methyl-1,4-naphthalenediol diphosp

Indication

Disease Entry	ICD 11	Status	REF
Coagulation defect	3B10.0	Approved	[1]
Obstructive jaundice		Approved	[2]

• Cross-matching ID:
  PubChem CID: 8555
  CAS Number: CAS 131-13-5
  TTD Drug ID: DMP9N85
  INTEDE Drug ID: DR0902

Molecule-Related Drug Atlas

Drug(s) Metabolized By NADPH-cytochrome P450 reductase (CPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[5]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[6]
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[7]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[8]
Benzphetamine	DMIJATC	Obesity	5B81	Approved	[9]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[10]
Amrubicin	DM6SGUB	Small-cell lung cancer	2C25.Y	Phase 3	[11]
Nitrobenzodiazepine	DM254EW	N. A.	N. A.	Investigative	[12]

Drug(s) Metabolized By Vitamin K1 2,3-epoxide reductase 1 (VKOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin K	DMN6EZY	Discovery agent	N.A.	Investigative	[13]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
NADPH-cytochrome P450 reductase (CPR)	DE3N2FM	NCPR_HUMAN	Substrate	[3]
Vitamin K1 2,3-epoxide reductase 1 (VKOR)	DEVRYQN	VKOR1_HUMAN	Substrate	[4]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Menadiol sodium diphosphate FDA Label
• [3] Creatinine sulfate/esculoside/hesperidin methyl chalcone/menadiol sodium phosphate/tranexamic acid actions.
• [4] SMPDB database: Vitamin K Metabolism
• [5] Kinetics of anthracycline antibiotic free radical formation and reductive glycosidase activity. Arch Biochem Biophys. 1983 May;223(1):68-75.
• [6] Lack of mechanism-based inactivation of rat hepatic microsomal cytochromes P450 by doxorubicin. Can J Physiol Pharmacol. 1999 Aug;77(8):589-97.
• [7] Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity. Free Radic Biol Med. 2008 Mar 15;44(6):1169-79.
• [8] Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy. Pharmacogenet Genomics. 2017 Sep;27(9):337-346.
• [9] On the mechanism of the inactivation of the major phenobarbital-inducible isozyme of rat liver cytochrome P-450 by chloramphenicol. J Biol Chem. 1985 Jul 15;260(14):8397-403.
• [10] Generation of free radicals during the reductive metabolism of nilutamide by lung microsomes: possible role in the development of lung lesions in patients treated with this anti-androgen. Biochem Pharmacol. 1992 Feb 4;43(3):654-7.
• [11] Characterization of the enzymes involved in the in vitro metabolism of amrubicin hydrochloride. Xenobiotica. 2005 Dec;35(12):1121-33.
• [12] Flavin-containing reductase: new perspective on the detoxification of nitrobenzodiazepine. Expert Opin Drug Metab Toxicol. 2010 Aug;6(8):967-81.
• [13] VKORC1L1, an enzyme mediating the effect of vitamin K in liver and extrahepatic tissues. Nutrients. 2018 Jul 26;10(8). pii: E970.