General Information of Drug (ID: DMP9N85)

Drug Name
Menadiol sodium diphosphate
Synonyms
Kappadione; Synkavit; Procoagulo; Synkavite; Thylokay; Kipca water soluble; Synkayvite; Menadiol sodium diphosphate; Menadione sodium phosphate; Sodium menadione diphosphate; Menadiol Sodium Diphosphate Anhydrous; UNII-R2L46WE615; Menadiol tetrasodium diphosphate; EINECS 205-012-1; Menadione diphosphate tetrasodium salt; 1:4-Naphthaquinol-bisdisodium phosphate; 131-13-5; Menadiol sodium diphosphate anhydrous [USAN]; R2L46WE615; 2-Methyl-1,4-naphthaquinol bis(disodium phosphate); Tetrasodium 2-methyl-1,4-naphthalenediol diphosp
Indication
Disease Entry ICD 11 Status REF
Coagulation defect 3B10.0 Approved [1]
Obstructive jaundice N.A. Approved [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski):
0
Molecular Weight 422.08
Logarithm of the Partition Coefficient Not Available
Rotatable Bond Count 2
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 8
ADMET Property
Clearance
The clearance of drug is 0.822 +/- 0.254 L/min []
Elimination
In tracer studies, it was found that approximately 20% of an injected dose of phylloquinone (Vitamin K metabolite) was found in the urine whereas about 40-50 % was excreted in the feces via the biliary system [3]
Half-life
The concentration or amount of drug in body reduced by one-half in 27.17 minutes [4]
Metabolism
The drug is metabolized via the enzymes such as microsomal NADPHCcytochrome P450 reductase and mitochondrial NADHCubiquinone oxidoreductase (complex I) [5]
Vd
The volume of distribution (Vd) of drug is 30.833 +/- 12.835 L [6]
Chemical Identifiers
Formula
C11H8Na4O8P2
IUPAC Name
tetrasodium;(2-methyl-4-phosphonatooxynaphthalen-1-yl) phosphate
Canonical SMILES
CC1=C(C2=CC=CC=C2C(=C1)OP(=O)([O-])[O-])OP(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]
InChI
InChI=1S/C11H12O8P2.4Na/c1-7-6-10(18-20(12,13)14)8-4-2-3-5-9(8)11(7)19-21(15,16)17;;;;/h2-6H,1H3,(H2,12,13,14)(H2,15,16,17);;;;/q;4*+1/p-4
InChIKey
GZBACHSOZNEZOG-UHFFFAOYSA-J
Cross-matching ID
PubChem CID
8555
CAS Number
131-13-5
UNII
R2L46WE615
DrugBank ID
DB09332
TTD ID
D09KGQ
INTEDE ID
DR0902
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
NADPH-cytochrome P450 reductase (CPR) DE3N2FM NCPR_HUMAN Substrate [7]
Vitamin K1 2,3-epoxide reductase 1 (VKOR) DEVRYQN VKOR1_HUMAN Substrate [8]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Menadiol sodium diphosphate FDA Label
3 Chapter 10. Vitamin K
4 Menadione
5 Madelain V, Nguyen TH, Olivo A, de Lamballerie X, Guedj J, Taburet AM, Mentre F: Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials. Clin Pharmacokinet. 2016 Aug;55(8):907-23. doi: 10.1007/s40262-015-0364-1.
6 A pharmacokinetic study with the high-dose anticancer agent menadione in rabbits
7 Creatinine sulfate/esculoside/hesperidin methyl chalcone/menadiol sodium phosphate/tranexamic acid actions.
8 SMPDB database: Vitamin K Metabolism