Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPA0BJ)

Drug Name
Uridine Diphosphate Galactose Drug Info
Synonyms
Udp galactose; uridine diphosphate galactose; UDP-D-galactopyranose; Uridine pyrophosphogalactose; Uridinediphosphogalactose; UDP-galactose; Udpgal; Uridine diphosphogalactose; UDP-alpha-D-Galactose; Uridine diphosphategalactose; GALACTOSE-URIDINE-5'-DIPHOSPHATE; 2956-16-3; UDP-Gal; CHEMBL439009; CHEBI:67119; UDP-D-galactose; UDP-alpha-D-galactopyranose; UDP-galactopyranose; Uridine-5'-diphosphate-alpha-D-galactose; Uridinediphosphate galactose; Uridine 5'-diphosphogalactose; GDU; UDPgalactose; Uridine 5'-(alpha-D-galactopyranosy
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
18068
ChEBI ID
CHEMBL439009
CAS Number
CAS 2956-16-3
TTD Drug ID
DMPA0BJ
INTEDE Drug ID
DR2132

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting UDP-glucose 4-epimerase (GALE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [6]
PSAMMAPLIN A DM6T0IQ Discovery agent N.A. Investigative [7]
UDP-glucose DMLT4JA Discovery agent N.A. Investigative [6]
Uridine-Diphosphate-N-Acetylgalactosamine DMXHO6J N. A. N. A. Investigative [6]
Uridine-Diphosphate-N-Acetylglucosamine DMEQSTP Discovery agent N.A. Investigative [8]
Tetramethylammonium Ion DMLEPYN Discovery agent N.A. Investigative [6]
Uridine-5'-Diphosphate DMDQKJB Discovery agent N.A. Investigative [6]
Phenyl-Uridine-5'-Diphosphate DM7J0YG Discovery agent N.A. Investigative [6]
Uridine-5'-Diphosphate-Mannose DMAYCQU Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
UDP-glucose 4-epimerase (GALE) TTGRHIB GALE_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Collagen galactosyltransferase (COLGALT2) DE8RIZD GT252_HUMAN Substrate [3]
Histo-blood group ABO system transferase (NAGAT) DESIA7R BGAT_HUMAN Substrate [4]
Xylosylprotein 4-beta-galactosyltransferase (XGalT-1) DEKRS6L B4GT7_HUMAN Substrate [5]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1782).
2 Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site. J Mol Biol. 2002 Apr 26;318(2):491-502.
3 Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases. Mol Cell Biol. 2009 Feb;29(4):943-52.
4 Structural basis for red cell phenotypic changes in newly identified, naturally occurring subgroup mutants of the human blood group B glycosyltransferase. Transfusion. 2007 May;47(5):864-75.
5 Probing the acceptor active site organization of the human recombinant beta1,4-galactosyltransferase 7 and design of xyloside-based inhibitors. J Biol Chem. 2015 Mar 20;290(12):7658-70.
6 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7 Identification of novel inhibitors of UDP-Glc 4'-epimerase, a validated drug target for african sleeping sickness. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5744-7.
8 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.