Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPAHJF)

Drug Name

Alpha,beta-methylene-dTTP Drug Info

Synonyms

alpha,beta-CH2-DTTP; alpha,beta-methylene-dTTP; alpha,beta-Methylenedeoxythymidine 5'-triphosphate; CHEMBL1162299; 24716-71-0; Thymidine, 5'-O-(1,3,5,5-tetrahydroxy-4-oxa-1,3,5-triphosphapent-1-yl)-, P,P',P''-trioxide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 15667207
CAS Number: CAS 24716-71-0
TTD Drug ID: DMPAHJF

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[2]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[3]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[4]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[5]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[3]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[6]
Penciclovir	DMOUMDV	Herpes simplex labialis	1F00.01	Approved	[7]
Famciclovir	DMJHLSD	Meniere disease	AB31.0	Approved	[8]
Valacyclovir Hydrochloride	DM5I1CE	Herpes simplex virus infection	1F00	Approved	[3]
Foscavir	DM9KJLZ	Cytomegalovirus retinitis	9B72.00	Approved	[6]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30)	TTIU7X1	DPOL_HHV11	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability... J Med Chem. 2008 Oct 23;51(20):6460-70.
2	Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):77-81.
5	Extensive oral shedding of human herpesvirus 8 in a renal allograft recipient. Oral Microbiol Immunol. 2009 Apr;24(2):109-15.
6	Drug targets in cytomegalovirus infection. Infect Disord Drug Targets. 2009 Apr;9(2):201-22.
7	Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs. 2009;69(2):151-66.
8	Penciclovir cream--improved topical treatment for herpes simplex infections. Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):214-8.