Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ45WH)

Drug Name

3,5-dichlorosalicylic acid Drug Info

Synonyms

3,5-DICHLOROSALICYLIC ACID; 3,5-Dichloro-2-hydroxybenzoic acid; 320-72-9; Benzoic acid, 3,5-dichloro-2-hydroxy-; Salicylic acid, 3,5-dichloro-; USAF DO-68; 2-Hydroxy-3,5-dichlorobenzoic acid; 3,5-Dichlorosalicylicacid; UNII-O6PXR32G3V; 3,5-Dichlorosalicyclic acid; HSDB 5562; EINECS 206-281-8; NSC 30109; 3,5-dichloro-2-hydroxy-benzoic acid; BRN 2210803; O6PXR32G3V; AI3-22601; CHEMBL449129; CNJGWCQEGROXEE-UHFFFAOYSA-N; C2U; ACMC-1CUK7; Salicylic acid,5-dichloro-; AC1Q3M9M; WLN: QVR BQ CG EG; DSSTox_RID_80582; DSSTox_CID_24914

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9445
ChEBI ID: CHEBI:165214
CAS Number: CAS 320-72-9
TTD Drug ID: DMQ45WH

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[2]
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[2]
Cyclopropyl	DMGFEPJ	Discovery agent	N.A.	Investigative	[3]
Trifluoroethanol	DMAWTUL	Discovery agent	N.A.	Investigative	[4]
Cyclobutyl	DM35PIJ	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Aldose reductase (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[5]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[6]
Fidarestat	DMZL1I8	Diabetic complication	5A2Y	Phase 3	[7]
Ranirestat	DMD5QRS	Diabetic neuropathy	8C0Z	Phase 3	[8]
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[9]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[8]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[10]
LIDORESTAT	DMA0RI9	Diabetic complication	5A2Y	Phase 2	[11]
QR-333	DMKVIWM	Diabetic neuropathy	8C0Z	Phase 2	[12]
ADMVA	DM819CO	Diabetic complication	5A2Y	Phase 2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[1]
Entamoeba Alcohol dehydrogenase 2 (Entamo ADH2)	TTJS7O4	ADH2_ENTHI	Inhibitor	[1]

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References

1	Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase. Bioorg Med Chem. 2009 Feb 1;17(3):1244-50.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) as a target for anti-amoebic agents. J Antimicrob Chemother. 2004 Jul;54(1):56-9.
4	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
5	Long-term effect of epalrestat, an aldose reductase inhibitor, on the development of incipient diabetic nephropathy in Type 2 diabetic patients. J Diabetes Complications. 2001 Sep-Oct;15(5):241-4.
6	Inhibition of human lens aldose reductase by flavonoids, sulindac and indomethacin. Biochem Pharmacol. 1983 Jul 1;32(13):1995-8.
7	Clinical efficacy of fidarestat, a novel aldose reductase inhibitor, for diabetic peripheral neuropathy: a 52-week multicenter placebo-controlled double-blind parallel group study. Diabetes Care. 2001 Oct;24(10):1776-82.
8	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2768).
9	Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes. J Nat Prod. 1996 Apr;59(4):443-5.
10	ClinicalTrials.gov (NCT02332005) 12-Month Efficacy and Safety of Diepalrestat in Adults With Diabetic Peripheral Neuropathy, a DB, Placebo-Controlled Study (DE-DPN). U.S. National Institutes of Health.
11	Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors ... J Med Chem. 2005 May 5;48(9):3141-52.
12	A multicenter, double-blind, safety study of QR-333 for the treatment of symptomatic diabetic peripheral neuropathy. A preliminary report. J Diabetes Complications. 2005 Sep-Oct;19(5):247-53.