Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQCW7V)

Drug Name

Tanaproget Drug Info

Synonyms

Tanaproget; 304853-42-7; NSP-989; UNII-W9F9H8GXWR; W9F9H8GXWR; 5-(4,4-Dimethyl-2-thioxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile; T98; Tanaproget [USAN:INN]; 1zuc; NSP 989; Tanaproget (USAN/INN); AC1NA08O; SCHEMBL62188; CHEMBL539163; GTPL7416; DTXSID00184556; PYVFWTPEBMRKSR-UHFFFAOYSA-N; ZINC6245719; BDBM50375821; AKOS030526776; SB17247; DB04787; CS-1550; NSP-989;NSP 989;NSP989; HY-15606; KB-145966; FT-0735521; W-5758; D06003

Indication

Disease Entry	ICD 11	Status	REF
Estrogen deficiency	FB83.0Y	Investigative	[1]

Cross-matching ID

PubChem CID: 4369524
CAS Number: CAS 304853-42-7
TTD Drug ID: DMQCW7V

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

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Drug(s) Targeting Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[3]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[4]
Ulipristal	DMBNI20	Contraception	QA21	Approved	[5]
Etonogestrel	DMKA8J4	Contraception	QA21	Approved	[6]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[7]
Segesterone acetate; ethinyl estradiol	DMFEGB0	Contraception	QA21	Approved	[8]
Norgestimate	DMYP4XC	Acne vulgaris	ED80	Approved	[6]
Dydrogesterone	DMAKIDV	Menstrual disorder	GA20.3	Approved	[9]
Medroxyprogesterone	DMBGWPH	Solid tumour/cancer	2A00-2F9Z	Approved	[9]
Ethynodiol Diacetate	DMZM84R	Contraception	QA21	Approved	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7416).
2	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3	Clinical pipeline report, company report or official report of lipocine.
4	Preclinical experience with two selective progesterone receptor modulators on breast and endometrium. Steroids. 2000 Oct-Nov;65(10-11):733-40.
5	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
6	Pharmacological profile of progestins. Maturitas. 2008 Sep-Oct;61(1-2):151-7.
7	Focus on anastrozole and breast cancer. Curr Med Res Opin. 2003;19(8):683-8.
8	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
9	Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharm... Steroids. 2008 Feb;73(2):222-31.
10	Contribution of functional groups of 19-nor-progestogens to binding to progesterone and estradiol-17beta receptors in rabbit uterus. Endocrinology. 1977 Jun;100(6):1579-84.