Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQNFZE)

Drug Name

Ad5-AC6 Drug Info

Synonyms

Corgenic; AC6 gene therapy, Collateral/UCSD; Adenylyl cyclase gene therapy, Collateral/UCSD; CHF gene therapy, Collateral/UCSD; Gene therapy (CHF), Collateral/USCD; Gene therapy (adenylate cyclase), Collateral/USCD

Indication

Disease Entry	ICD 11	Status	REF
Cardiac failure	BD10-BD13	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMQNFZE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Adenylate cyclase (ADCY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[3]
N6-CYCLOPENTYLADENOSINE	DMD6AJO	Discovery agent	N.A.	Investigative	[4]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[3]
NSC-88915	DM9WIHJ	Solid tumour/cancer	2A00-2F9Z	Investigative	[5]
2-hydroxy-17beta-estradiol	DMM9Z0B	Discovery agent	N.A.	Investigative	[5]
2,5-didesoxy-3-ATP	DM5CWM0	Discovery agent	N.A.	Investigative	[5]
Adenosine-5'-Rp-Alpha-Thio-Triphosphate	DMKY7T8	Discovery agent	N.A.	Investigative	[6]
DEOXYADENOSINE	DMS6X1I	N. A.	N. A.	Investigative	[7]
NSC-270718	DMUNIWE	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenylate cyclase (ADCY)	TT2QM9D	NOUNIPROTAC	Modulator	[2]

------------------------------------------------------------------------------------

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013170)
2	Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90.
5	Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64.
6	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
7	Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. J Med Chem. 2004 Feb 26;47(5):1207-13.