Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TT2QM9D)

DTT Name Adenylate cyclase (ADCY)
Synonyms Adenylyl cyclase; ATP pyrophosphate-lyase
Gene Name ADCY
DTT Type
Literature-reported target
 [1]
BioChemical Class
Phosphorus-oxygen lyase
UniProt ID
NOUNIPROTAC
TTD ID
T25889
Function
Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp- cAMP, which then induces its own transcription again.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ad5-AC6 DMQNFZE Cardiac failure BD10-BD13 Terminated [1]
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9 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
2,5-didesoxy-3-ATP DM5CWM0 Discovery agent N.A. Investigative [2]
2-hydroxy-17beta-estradiol DMM9Z0B Discovery agent N.A. Investigative [2]
Adenosine-5'-Rp-Alpha-Thio-Triphosphate DMKY7T8 Discovery agent N.A. Investigative [3]
DEOXYADENOSINE DMS6X1I N. A. N. A. Investigative [4]
N6-CYCLOPENTYLADENOSINE DMD6AJO Discovery agent N.A. Investigative [5]
NSC-270718 DMUNIWE Discovery agent N.A. Investigative [2]
NSC-88915 DM9WIHJ Solid tumour/cancer 2A00-2F9Z Investigative [2]
[3H]alphabeta-meATP DMWV5C3 Discovery agent N.A. Investigative [6]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [6]
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⏷ Show the Full List of 9 Investigative Drug(s)

References

1 Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758.
2 Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64.
3 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
4 Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. J Med Chem. 2004 Feb 26;47(5):1207-13.
5 Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90.
6 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.