Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR48NG)

Drug Name

5'-deoxythymidine Drug Info

Synonyms

5'-Deoxythymidine; 3458-14-8; Thymidine, 5'-deoxy-; 5'-Ddthd; 2',5'-Dideoxythymidine; 5'-Deoxythymidine, 98%; AC1L22MY; SCHEMBL2056693; CHEMBL465901; CTK1C3983; DTXSID70188127; MolPort-003-930-221; ZINC5765072; AKOS015892581; 5 inverted exclamation marka-Deoxythymidine; FT-0772769; C-44347; I03-1540; 5''-Deoxythymidine; AC1L22MY; SureCN2056693;; 2 inverted exclamation marka,5 inverted exclamation marka-Dideoxythymidine; 1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 65120
CAS Number: CAS 3458-14-8
TTD Drug ID: DMR48NG

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Mycobacterium Thymidine monophosphate kinase (MycB tmk)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[2]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[3]
2'-deoxythymidine triphosphate	DM9OEJT	Discovery agent	N.A.	Investigative	[2]
Deoxythymidine	DMR90HY	Discovery agent	N.A.	Investigative	[2]
Diphosphate	DMHY30B	Discovery agent	N.A.	Investigative	[2]
Thymidine-5'-Phosphate	DMKM6NQ	Discovery agent	N.A.	Investigative	[2]
P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate	DMM4VWD	Discovery agent	N.A.	Investigative	[4]
3'-Azido-3'-Deoxythymidine-5'-Monophosphate	DMU08MN	Discovery agent	N.A.	Investigative	[2]
5-Hydroxymethyluridine-2'-Deoxy-5'-Monophosphate	DMWVCJ1	Discovery agent	N.A.	Investigative	[2]
CHLORODEOXYURIDINE	DMQT3WJ	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mycobacterium Thymidine monophosphate kinase (MycB tmk)	TT5B8AX	KTHY_MYCTU	Inhibitor	[1]

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References

1	Thymidylate kinase as target enzyme for 5'-deoxythymidine and various 5'-deoxy-5'-halogeno pyrimidine nucleosides. Acta Biol Med Ger. 1969;23(6):Suppl:K 19+.
2	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
4	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
5	Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial ac... Bioorg Med Chem. 2008 Jun 1;16(11):6075-85.