Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR6USG)

Drug Name

PELITREXOL Drug Info

Synonyms

AG-2037; Pelitrexol < USAN; AG-2032 (racemate); AG-2038 ((6R)-isomer); N-[5-[2-[2-Amino-4-oxo-3,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6(S)-yl]ethyl]-4-methylthien-2-ylcarbonyl]-L-glutamic acid

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]

Cross-matching ID

PubChem CID: 135431074
CAS Number: CAS 446022-33-9
TTD Drug ID: DMR6USG

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glycinamide ribonucleotide formyltransferase (GART)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY309887	DMJPCHK	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
10-Formyl-5,8,10-Trideazafolic Acid	DMEBHML	Discovery agent	N.A.	Investigative	[4]
Glycinamide Ribonucleotide	DMW180Y	Discovery agent	N.A.	Investigative	[4]
(10r)-10-Formyl-5,8,10-Trideazafolic Acid	DMVTLF9	Discovery agent	N.A.	Investigative	[4]
10-trifluoroacetyl-DDACTHF	DMEAGI6	Discovery agent	N.A.	Investigative	[5]
Dideazaacyclotetrahydrofolic acid	DM9WU3R	Discovery agent	N.A.	Investigative	[6]
10-CF3C(OH)2-DDACTHF	DMQOUJ7	Discovery agent	N.A.	Investigative	[4]
Dideazafolate	DMAIOC9	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycinamide ribonucleotide formyltransferase (GART)	TTEXB9Z	PUR2_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT00078468) Study of the GARFT Inhibitor AG2037 in Patients With Metastatic Colorectal Cancer Who Failed Treatment. U.S. National Institutes of Health.
2	Results of 2 phase I studies of intravenous (iv) pelitrexol (AG2037), a glycinamide ribonucleotide formyltransferase (GARFT) inhibitor, in patients (pts) with solid tumors. J Clin Oncol (Meeting Abstracts) July 2004 vol. 22 no. 14_suppl 3075.
3	New antimetabolites in cancer chemotherapy and their clinical impact. Br J Cancer. 1998;78 Suppl 3:1-7.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. J Med Chem. 2006 May 18;49(10):2998-3002.
6	Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 2008 Sep 11;51(17):5441-8.
7	N10-substituted 5,8-dideazafolate inhibitors of glycinamide ribonucleotide transformylase. J Med Chem. 1987 Jul;30(7):1254-6.