Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRFWGK)

Drug Name
Novobiocin Drug Info
Synonyms
Albamix; Albamycin; Cardelmycin; Cathocin; Cathomycin; Inamycin; NOV; Novobiocina; Novobiocine; Novobiocinum; Robiocina; Sirbiocina; Spheromycin; Stilbiocina; Streptonivicin; Crystallinic acid; Novobiocin sodium salt; PA 93; U 6391; Albamycin (TN); Antibiotic PA-93; Novo-R; Novobiocin [INN:BAN]; Novobiocina [INN-Spanish]; Novobiocine [INN-French]; Novobiocinum [INN-Latin]; Streptonivicin (*Sodium salt*); [(3R,4S,5R,6R)-5-hydroxy-6-[2-hydroxy-3-[[4-hydroxy-3-(3-methylbut-2-enyl)benzoyl]amino]-8-methyl-4-oxochromen-7-yl]oxy-3-methoxy-2,2-dimethyloxan-4-yl] carbamate; N-[7-[[3-O-(Aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-.beta.-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-butenyl); (3R,4S,5R,6R)-5-hydroxy-6-{[4-hydroxy-3-({[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]carbonyl}amino)-8-methyl-2-oxo-2H-chromen-7-yl]oxy}-3-methoxy-2,2-dimethyltetrahydro-2H-pyran-4-yl carbamate; (3r,4s,5r,6r)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzoyl]amino}-8-methyl-4-oxo-4h-chromen-7-yl)oxy]-3-methoxy-2,2-dimethyltetrahydro-2h-pyran-4-yl carbamate(non-preferred name); 7-(3-(O-Carbamoyl)-4-(O-methyl)-5,5-dimethyl-alpha-L-lyxopyranosyloxy)-4-hydroxy-3-(4-hydroxy-3-(3-methyl-2-butenyl)benzamidol)-8-methylcumarin; 7-(Carbamoyltetrahydro-3-hydroxy-5-methoxy-6,6-dimethylpyran-2-yloxy)-4-hydroxy-3-(4-hydroxy-3-(3-methylbut-2-enyl)benzamide)-8-methyl-2H-chromen-2-one
Indication
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [1]
Therapeutic Class
Antibiotics
Cross-matching ID
PubChem CID
54675769
ChEBI ID
CHEBI:28368
CAS Number
CAS 303-81-1
TTD Drug ID
DMRFWGK
VARIDT Drug ID
DR00660

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase II (TOP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [6]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [7]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [6]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [8]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [6]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [6]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [9]
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [6]
Podofilox DMT2EJP Condyloma 1A95 Approved [10]
Enoxacin DMYTE6L Acute gonococcal cervicitis Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-2 (CDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [12]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [14]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [15]
Panobinostat DM58WKG Chronic graft versus host disease Approved [16]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [17]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [18]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [20]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [22]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [24]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [25]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [26]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [27]
Bortezomib DMNO38U Leukemia Approved [28]
Omacetaxine mepesuccinate DMPU2WX Adult acute monocytic leukemia Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [31]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [34]
Gefitinib DM15F0X Colon adenocarcinoma Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [37]
Selenium DM25CGV N. A. N. A. Approved [38]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [39]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [41]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Gefitinib DM15F0X Colon adenocarcinoma Approved [42]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [43]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [44]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [45]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [48]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [49]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Gene/Protein Processing [3]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [4]
Cadherin-2 (CDH2) OTH0Y56P CADH2_HUMAN Gene/Protein Processing [3]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Protein Interaction/Cellular Processes [5]

References

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21 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
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