Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRGVNJ)

Drug Name

(-)-uniflorine A Drug Info

Synonyms

(-)-uniflorine A; CHEMBL1076191; Uniflorine A

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Lysosomal alpha-glucosidase (GAA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Avalglucosidase alfa	DMPW5UF	Pompe disease	5C51.3	Approved	[2]
Deoxynojirimycin	DM2ATZB	Pompe disease	5C51.3	Phase 3	[3]
BMN-701	DM94Y6O	Pompe disease	5C51.3	Phase 3	[4]
AT845	DMZJIIB	Pompe disease	5C51.3	Phase 2	[5]
SALACINOL	DMVKQT8	N. A.	N. A.	Phase 1/2	[6]
SPK-3006	DMK9DG5	Pompe disease	5C51.3	Phase 1/2	[7]
GZ402666	DMGO6M1	Pompe disease	5C51.3	Phase 1	[8]
5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)-6-chloroindolin-2-one	DMAJWLD	Pompe disease	5C51.3	Preclinical	[9]
Alpha-Homonojirimycin	DMT17H0	Discovery agent	N.A.	Investigative	[3]
7-O-b-D-Glucopyranosyl-a-homonojirimycin	DM8IY3D	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lysosomal alpha-glucosidase (GAA)	TTLPC70	LYAG_HUMAN	Inhibitor	[1]

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References

1	Total synthesis of (-)-uniflorine A. J Nat Prod. 2009 Nov;72(11):2058-60.
2	ClinicalTrials.gov (NCT02782741) Study to Compare the Efficacy and Safety of Enzyme Replacement Therapies Avalglucosidase Alfa and Alglucosidase Alfa Administered Every Other Week in Patients With Late-onset Pompe Disease Who Have Not Been Previously Treated for Pompe Disease (COMET). U.S. National Institutes of Health.
3	In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6.
4	Clinical pipeline report, company report or official report of BioMarin Pharma.
5	Muscle-directed gene therapy corrects Pompe disease and uncovers species-specific GAA immunogenicity. EMBO Mol Med. 2022 Jan 11;14(1):e13968.
6	Alpha-glucosidase inhibitor from Kothala-himbutu (Salacia reticulata WIGHT). J Nat Prod. 2008 Jun;71(6):981-4.
7	Clinical pipeline report, company report or official report of Spark Therapeutics
8	ClinicalTrials.gov (NCT01898364) Safety and Efficacy Evaluation of Repeat neoGAA Dosing in Late Onset Pompe Disease Patients.. U.S. National Institutes of Health.
9	5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)indolin-2-one Analogs as Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2. N.A.. N.A.