Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRM6ES)

Drug Name
Benzylamine Drug Info
Synonyms
Aminotoluene; BENZYLAMINE; Benzenemethanamine; Monobenzylamine; Moringine; N-Benzylamine; Phenylmethylamine; Sumine 2005; Sumine 2006; TOLUENE,ALPHA-AMINO; benzyl amine; benzyl-amine; omega-Aminotoluene; phenylmethanamine; (Aminomethyl)benzene; (Phenylmethyl)amine; .alpha.-Aminotoluene; .omega.-Aminotoluene; 1-phenylmethanamine; 100-46-9; 1utj; 1utn; 2bza; A1O31ROR09; AI3-15299; BRN 0741984; CHEBI:40538; CHEMBL522; EINECS 202-854-1; HSDB 2795; MFCD00008106; NSC 8046; UNII-A1O31ROR09; a-Aminotoluene; alpha-Aminotoluene
Cross-matching ID
PubChem CID
7504
ChEBI ID
CHEBI:40538
CAS Number
CAS 100-46-9
TTD Drug ID
DMRM6ES
INTEDE Drug ID
DR1959

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Monoamine oxidase type A (MAO-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [3]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [4]
Naratriptan DMO50U2 Headache 8A80-8A84 Approved [5]
Safinamide mesylate DM0J2ZT Parkinson disease 8A00.0 Approved [6]
Almotriptan malate DMFG5ST N. A. N. A. Approved [7]
SEROTONIN DMOFCRY Discovery agent N.A. Investigative [1]
PHENETHYLAMINE DMX0G4F Discovery agent N.A. Investigative [1]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Metabolized By Copper amine oxidase (AOC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tresperimus DMOVBSF Autoimmune diabetes 5A10 Discontinued in Phase 3 [8]
tyramine DM4UXT1 Discovery agent N.A. Investigative [2]
PHENETHYLAMINE DMX0G4F Discovery agent N.A. Investigative [2]
Methylamine DMTPL4W N. A. N. A. Investigative [2]
Drug(s) Metabolized By Semicarbazide-sensitive amine oxidase (AOC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
tyramine DM4UXT1 Discovery agent N.A. Investigative [2]
PHENETHYLAMINE DMX0G4F Discovery agent N.A. Investigative [2]
Methylamine DMTPL4W N. A. N. A. Investigative [2]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Monoamine oxidase type A (MAO-A) DERE4TU AOFA_HUMAN Substrate [1]
Copper amine oxidase (AOC3) DE6SOC5 AOC3_HUMAN Substrate [2]
Semicarbazide-sensitive amine oxidase (AOC2) DE8DP90 AOC2_HUMAN Substrate [2]

References

1 Do monomeric vs dimeric forms of MAO-A make a difference? A direct comparison of the catalytic properties of rat and human MAO-A's. J Neural Transm (Vienna). 2007;114(6):721-4.
2 The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57.
3 Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study. J Neurooncol. 2019 Nov;145(2):287-294.
4 Med-psych drug-drug interactions update. Psychosomatics. 2002 May;43(3):245-7.
5 Migraine pharmacotherapy with oral triptans: a rational approach to clinical management. Expert Opin Pharmacother. 2000 Mar;1(3):391-404.
6 Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem. 2007 Oct 4;50(20):4909-16.
7 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
8 Metabolism of tresperimus by rat aorta semicarbazide-sensitive amine oxidase (SSAO). Fundam Clin Pharmacol. 2002 Dec;16(6):461-70.