Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMS7OU8)

Drug Name

Elapegademase Drug Info

Synonyms

Elapegademase [INN]; UNII-9R3D3Y0UHS; Elapegademase [USAN:INN]; 9R3D3Y0UHS

Indication

Disease Entry	ICD 11	Status	REF
Adenosine deaminase defciency	4A01.1	Approved	[1]
Immunodeficiency	4A00-4A85	Phase 3	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Adenosine deaminase (ADA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[3]
Fludarabine	DMVRLT7	Acute myelogenous leukaemia	2A41	Approved	[4]
Pentostatin	DM0HXDS	Acute graft versus host disease	4B24.0	Approved	[4]
GSK2696273	DMP5O1U	Chronic pain	MG30	Preregistration	[5]
OTL-101	DMLMS6J	Severe combined immunodeficiency	4A01.10	Phase 3	[6]
Ex vivo adenosine deaminase-transduced hematopoietic stem cell therapy	DMIREUZ	Immunodeficiency	4A00-4A85	Phase 1/2	[5]
EHNA	DM014WS	Discovery agent	N.A.	Investigative	[7]
3-(6-Amino-purin-9-yl)-6-phenyl-hexan-2-ol	DMZT8QX	Discovery agent	N.A.	Investigative	[8]
3-(6-Amino-purin-9-yl)-8-phenyl-octan-2-ol	DMAIS1D	Discovery agent	N.A.	Investigative	[8]
1-Deaza-Adenosine	DMG0VN6	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2	ClinicalTrials.gov (NCT01420627) EZN-2279 in Patients With ADA-SCID. U.S. National Institutes of Health.
3	Cladribine: from the bench to the bedside--focus on hairy cell leukemia. Expert Rev Anticancer Ther. 2004 Oct;4(5):745-57.
4	Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
5	Clinical pipeline report, company report or official report of GlaxoSmithKline.
6	Clinical pipeline report, company report or official report of Orchard Therapeutics.
7	Tight-binding inhibitors--IV. Inhibition of adenosine deaminases by various inhibitors. Biochem Pharmacol. 1977 Mar 1;26(5):359-67.
8	Adenosine deaminase inhibitors: synthesis and biological evaluation of unsaturated, aromatic, and oxo derivatives of (+)-erythro-9-(2'S-hydroxy-3'R... J Med Chem. 2000 Nov 30;43(24):4694-700.
9	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.