Details of the Drug

General Information of Drug (ID: DMS7OU8)

Drug Name
Elapegademase
Synonyms Elapegademase [INN]; UNII-9R3D3Y0UHS; Elapegademase [USAN:INN]; 9R3D3Y0UHS
Indication
Disease Entry ICD 11 Status REF
Adenosine deaminase defciency 4A01.1 Approved [1]
Immunodeficiency 4A00-4A85 Phase 3 [2]
Affected Organisms
Humans
ATC Code
L03AX21: Elapegademase
L03AX: Other immunostimulants
L03A: IMMUNOSTIMULANTS
L03: IMMUNOSTIMULANTS
L: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Sequence
AQTPAFNKPKVELHVHLDGAIKPETILYYGRKRGIALPADTPEELQNIIGMDKPLSLPEF
LAKFDYYMPAIAGSREAVKRIAYEFVEMKAKDGVVYVEVRYSPHLLANSKVEPIPWNQAE
GDLTPDEVVSLVNQGLQEGERDFGVKVRSILCCMRHQPSWSSEVVELCKKYREQTVVAID
LAGDETIEGSSLFPGHVKAYAEAVKSGVHRTVHAGEVGSANVVKEAVDTLKTERLGHGYH
TLEDTTLYNRLRQENMHFEVCPWSSYLTGAWKPDTEHPVVRFKNDQVNYSLNTDDPLIFK
STLDTDYQMTKNEMGFTEEEFKRLNINAAKSSFLPEDEKKELLDLLYKAYGMPSPA
ADMET Property
Absorption AUC
The area under the plot of plasma concentration (AUC) of drug is 33000000 micromolh/L []
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 60 h []
Metabolism
The drug is metabolized via proteases to small peptides and individual amino acids []
Cross-matching ID
PubChem CID
121488177
UNII
9R3D3Y0UHS
DrugBank ID
DB14712
TTD ID
D01VEJ
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenosine deaminase (ADA) TTLP57V ADA_HUMAN Modulator [1]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

References

1 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2 ClinicalTrials.gov (NCT01420627) EZN-2279 in Patients With ADA-SCID. U.S. National Institutes of Health.