Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSAOWQ)

Drug Name

Lactulose Drug Info

Synonyms

Cephulac;Cholac;Heptalac;Enulose;Enulose

Indication

Disease Entry	ICD 11	Status	REF
Constipation	DD91.1	Approved	[1]
Hepatic encephalopathy	DB99.5	Approved	[2]
Ornithine transcarbamylase deficiency	5C50.AY	Approved	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Metabolized By Beta-galactosidase (bgaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LS-69767	DM8VBQJ	N. A.	N. A.	Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Glycosyl hydrolase (glyH)	DEPB9C2	A0A379KQ43_PSEPU	Substrate	[3]
Beta-glucosidase (bglA)	DE235K6	Q3Y0M8_ENTFD	Substrate	[3]
Beta-galactosidase (bgaB)	DEIEY19	BGAL_CROS8	Substrate	[3]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Lactulose FDA Label
3	In vitro fermentation of lactulose by human gut bacteria. J Agric Food Chem. 2014 Nov 12;62(45):10970-7.
4	In vitro fermentation of fructooligosaccharides with human gut bacteria. Food Funct. 2015 Mar;6(3):947-54.