Details of the Drug-Related molecule(s) Interaction Atlas

CTK0H-9987 Drug Info

Neoprontosil; Neoprontosil, disodium salt; Neoprontsil; PRONTOCIL; ZINC261161909; ZINC28863804; AZOSULFAMIDE; 132-38-7; 2,7-Naphthalenedisulfonic acid, 6-(acetylamino)-3-((4-(aminosulfonyl)phenyl)azo)-4-hydroxy-; 2,7-Naphthalenedisulfonic acid, 6-(acetylamino)-3-[[4-(aminosulfonyl)phenyl]azo]-4-hydroxy-; 2,7-Naphthalenedisulfonic acid, 6-(acetylamino)-3-[[4-(aminosulfonyl)phenyl]azo]-4-hydroxy-, disodium salt; AABSSN; BDBM50221406; CHEMBL237251; CTK0H9987; DTXSID0074500

Cross-matching ID

PubChem CID

8625

TTD Drug ID

DMSGYNP

INTEDE Drug ID

DR2353

General Information of Drug (ID: DMSGYNP)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Azoreductase (azoR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Balsalazide	DM7I1T9	Inflammatory bowel disease	DD72	Approved	[3]
SC-47085	DMGH4Q0	N. A.	N. A.	Phase 2	[4]
CB1954	DMVP4YK	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[5]
Ipsalazide	DMYEM59	N. A.	N. A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Azoreductase (azoR)	DEEHWOG	AZOR_ECOLI	Substrate	[1]
Azoreductase (azoR)	DETP059	AZOR_SHIDS	Substrate	[2]
Azoreductase (azoR)	DEPF49Q	AZOR_CLOP1	Substrate	[2]
Azoreductase (azoR)	DEMW0RC	AZOR_ECOLI	Substrate	[2]

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References

1	The role of the gut flora in the metabolism of prontosil and neoprontosil in the rat. Xenobiotica. 1971 Mar;1(2):143-56.
2	Developing a metagenomic view of xenobiotic metabolism. Pharmacol Res. 2013 Mar;69(1):21-31.
3	Studies of two novel sulfasalazine analogs, ipsalazide and balsalazide. Dig Dis Sci. 1983 Jul;28(7):609-15.
4	Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease. Drugs. 1991 Apr;41(4):647-64.
5	Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Biochem Pharmacol. 2010 Mar 1;79(5):678-87.