Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTIM1E)

Drug Name
PMID26161698-Compound-34 Drug Info
Cross-matching ID
TTD Drug ID
DMTIM1E

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Cyclin-dependent kinase 7 (CDK7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
R-roscovitine DMSH108 Non-small-cell lung cancer 2C25.Y Phase 2 [2]
Samuraciclib DM54FQA Breast cancer 2C60-2C65 Phase 1/2 [3]
SNS-032 DMEITAS Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
BTX-A51 DMC8XHQ Advanced solid tumour 2A00-2F9Z Phase 1 [5]
SY-1365 DMK48PM Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
LY3405105 DMB51K2 Solid tumour/cancer 2A00-2F9Z Phase 1 [7]
SY-5609 DMNW3LH Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
Oxazolyl methylthiothiazole derivative 1 DMZM6FW N. A. N. A. Patented [1]
Roscovitine derivative 1 DMD1G3Z N. A. N. A. Patented [1]
Tricyclic benzimidazole derivative 1 DM5SD9E N. A. N. A. Patented [1]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cyclin-dependent kinase 7 (CDK7) TTQYF7G CDK7_HUMAN Inhibitor [1]

References

1 Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
2 Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
3 The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer. Br J Cancer. 2023 Jun;128(12):2326-2337.
4 Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2009 May 7;113(19):4637-45.
5 Clinical pipeline report, company report or official report of BioTheryX.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 CDK7 inhibitors as anticancer drugs. Cancer Metastasis Rev. 2020 Sep;39(3):805-823.
8 Clinical pipeline report, company report or official report of Syros Pharmaceuticals.