Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTSLGF)

Drug Name

LDN-91946 Drug Info

Synonyms

compound 7

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

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Drug(s) Targeting Ubiquitin thioesterase L1 (UCHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LDN-57444	DM1982I	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
NSC632839	DMQRZ4T	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Ubiquitin thioesterase L1 (UCHL1)	TTX9IFP	UCHL1_HUMAN	Inhibitor	[1]

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References

1	Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32.
2	Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells. Int J Mol Sci. 2019 Jul 31;20(15):3733.
3	Ubiquitin C-Terminal Hydrolase L1 regulates autophagy by inhibiting autophagosome formation through its deubiquitinating enzyme activity. Biochem Biophys Res Commun. 2018 Mar 4;497(2):726-733.