Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUKMC8)

Drug Name
Phloroglucinol Drug Info
Synonyms
phloroglucinol; 108-73-6; Benzene-1,3,5-triol; 1,3,5-trihydroxybenzene; 1,3,5-benzenetriol; Phloroglucin; Phloroglucine; Spasfon-Lyoc; s-Trihydroxybenzene; 5-Hydroxyresorcinol; Benzene-s-triol; 3,5-Dihydroxyphenol; Benzene, trihydroxy; sym-Trihydroxybenzene; 5-Oxyresorcinol; Dilospan S; Floroglucinol; Floroglucin; Phloroglucinol anhydrous; 5-Oxyresorcinolphloroglucin; 1,3,5-THB; 1,3,5-Trihydroxycyclohexatriene; 1,3,5-Triol; Floroglucin [Czech]; Floroglucinol [Czech]; Benzene, 1,3,5-trihydroxy-; UNII-DHD7FFG6YS; 5-Benzenetriol; NSC 157
Indication
Disease Entry ICD 11 Status REF
Urinary tract disease GC2Z Approved [1]
Cross-matching ID
PubChem CID
359
ChEBI ID
CHEBI:16204
CAS Number
CAS 108-73-6
TTD Drug ID
DMUKMC8
INTEDE Drug ID
DR2153

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
DOT
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [5]
Gefitinib DM15F0X Colon adenocarcinoma Approved [6]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [7]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [8]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [9]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [10]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [9]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [11]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [12]
Methotrexate DM2TEOL Anterior urethra cancer Approved [13]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [14]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [15]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [16]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [17]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [18]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [5]
Verapamil DMA7PEW Angina pectoris BA40 Approved [19]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [20]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [21]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [23]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [24]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [25]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [22]
Gefitinib DM15F0X Colon adenocarcinoma Approved [26]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [27]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [28]
Selenium DM25CGV N. A. N. A. Approved [29]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [30]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [31]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [33]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [34]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [35]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [36]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [37]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [38]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [39]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [41]
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Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [42]
Gefitinib DM15F0X Colon adenocarcinoma Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Selenium DM25CGV N. A. N. A. Approved [29]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [50]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [51]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [52]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [5]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [20]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [53]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [54]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [8]
Meloxicam DM2AR7L Arthritis FA20 Approved [55]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [56]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [57]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [14]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [41]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [5]
Verapamil DMA7PEW Angina pectoris BA40 Approved [19]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [58]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [53]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Meloxicam DM2AR7L Arthritis FA20 Approved [61]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [10]
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Drug(s) Affected By Growth/differentiation factor 15 (GDF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [62]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [66]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [69]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [70]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Phloroglucinol reductase (PHGR) Main DME DE69WKO PHGR_EUBOX Substrate [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [3]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [4]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [3]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Post-Translational Modifications [4]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Gene/Protein Processing [4]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Protein Interaction/Cellular Processes [4]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Post-Translational Modifications [4]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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26 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
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43 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
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49 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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63 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
64 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
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70 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.