Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUOPBF)

Drug Name

BILD-1263 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Herpes simplex virus infection	1F00	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

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Drug(s) Targeting Herpes simplex virus Ribonucleoside-diphosphate reductase (HSV RIR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BILD-1351	DMR01WE	Herpes simplex virus infection	1F00	Terminated	[3]
BILD-733	DMAU5WL	Herpes simplex virus infection	1F00	Terminated	[4]
BILD-1357	DMZMUG2	Herpes simplex virus infection	1F00	Terminated	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Herpes simplex virus Ribonucleoside-diphosphate reductase (HSV RIR1)	TTMJX4U	RIR1_HHV11	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004429)
2	Evaluation of a peptidomimetic ribonucleotide reductase inhibitor with a murine model of herpes simplex virus type 1 ocular disease. Antimicrob Agents Chemother. 1996 May;40(5):1078-84.
3	The antiviral activity of the ribonucleotide reductase inhibitor BILD 1351 SE in combination with acyclovir against HSV type-1 in cell culture. Antiviral Res. 1998 Jul;39(1):35-46.
4	Resistance of herpes simplex virus type 1 to peptidomimetic ribonucleotide reductase inhibitors: selection and characterization of mutant isolates. J Virol. 1996 Feb;70(2):787-93.
5	Peptidomimetic inhibitors of herpes simplex virus ribonucleotide reductase with improved in vivo antiviral activity. J Med Chem. 1996 Oct 11;39(21):4173-80.