Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUPWQT)

Drug Name

PGF1alpha Drug Info

Synonyms

U 18714; prostaglandin F1alpha

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Cation channel sperm-associated protein 3 (CatSper3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NNC55-0396	DMID3F7	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Cation channel sperm-associated protein 1 (CatSper1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NNC55-0396	DMID3F7	Discovery agent	N.A.	Investigative	[3]
HC-056456	DMOG1Q4	Discovery agent	N.A.	Investigative	[4]
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Drug(s) Targeting Cation channel sperm-associated protein (CatSper)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NNC55-0396	DMID3F7	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Cation channel sperm-associated protein 2 (CatSper2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NNC55-0396	DMID3F7	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cation channel sperm-associated protein (CatSper)	TTWOCZI	NOUNIPROTAC	Activator	[2]
Cation channel sperm-associated protein 1 (CatSper1)	TT5CISB	CTSR1_HUMAN	Activator	[2]
Cation channel sperm-associated protein 2 (CatSper2)	TTOEGC4	CTSR2_HUMAN	Activator	[2]
Cation channel sperm-associated protein 3 (CatSper3)	TTP52ZV	CTSR3_HUMAN	Activator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5412).
2	Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91.
3	The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature. 2011 Mar 17;471(7338):382-6.
4	Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4(8):e6844.