Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVE69Y)

Drug Name

NSC-119913 Drug Info

Synonyms

NSC119913; NSC-119913; MLS-0111619.0001; 7-methyl-2-(3,4,5-trihydroxy-6-oxoxanthen-9-yl)bicyclo[2.2.1]hept-5-ene-3-carboxylic acid; 7-methyl-3-(4,5,6-trihydroxy-3-oxo-3H-xanthen-9-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid; 7-methyl-2-(3,4,5-trihydroxy-6-oxo-xanthen-9-yl)bicyclo[2.2.1]hept-5-ene-3-carboxylic acid; AC1L6U1G; CHEMBL471004; cid_274125; SCHEMBL2777685; BDBM42000; CTK6B4006; NCI60_000473; 7-methyl-3-(4,6-trihydroxy-3-oxo-3H-xanthen-9-yl)bicyclo[2.2.1]hept-5-ene-2-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 274125
TTD Drug ID: DMVE69Y

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Lipopolysaccharide-associated protein 1 (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NSC-119911	DM1MRFW	Discovery agent	N.A.	Investigative	[1]
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Drug(s) Targeting Heat shock protein 70 (HSP70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AG-858	DMNQ5T2	leukaemia	2A60-2B33	Phase 2	[2]
AEG-33773	DMSBLOU	Diabetic neuropathy	8C0Z	Phase 2	[3]
Enkastim-ev	DMGLHYU	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
Minnelide 001	DM5VEN9	Gastric adenocarcinoma	2B72	Phase 1	[5]
BRX-005	DMTDWIE	Diabetic foot ulcer	BD54	Phase 1	[6]
Minnelide	DMDER9S	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
AG-707	DM7PLMJ	Herpes simplex virus infection	1F00	Phase 1	[8]
H-103	DMRCHOU	Metastatic malignant neoplasm	2D50-2E09	Phase 1	[9]
NK-1001	DMZMQDN	Atrial fibrillation	BC81.3	Discontinued in Phase 2	[10]
Bimoclomol	DMOP95G	Diabetic complication	5A2Y	Discontinued in Phase 2	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Heat shock protein 70 (HSP70)	TTHYBIX	HS71A_HUMAN; HS71B_HUMAN	Inhibitor	[1]
Lipopolysaccharide-associated protein 1 (HSPA8)	TTMQL3K	HSP7C_HUMAN	Inhibitor	[1]

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References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.
2	Preparation of a Heat Shock Proteins 70-based Vaccine from DC-tumor fusion cells. Methods Mol Biol. 2011; 787: 255-265.
3	Mitogen-activated protein kinase kinase kinase 12 (MAP3K12; DLK); c-jun N-terminal kinase (JNK). SciBX 2(11); doi:10.1038/scibx.2009.462. March 19 2009
4	Company report (Multimmune)
5	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
6	Cardiovascular effects of BRX-005 comparison to bimoclomol. Life Sci. 2000 Aug 25;67(14):1783-9.
7	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
8	A heat shock protein based polyvalent vaccine targeting HSV-2: CD4(+) and CD8(+) cellular immunity and protective efficacy. Vaccine. 2011 Nov 3;29(47):8530-41.
9	A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patients. Gene Ther. 2009 Mar;16(3):376-82.
10	Novel therapeutic targets in the management of atrial fibrillation. Am J Cardiovasc Drugs. 2014 Dec;14(6):403-21.
11	Bimoclomol elevates heat shock protein 70 and cytoprotects rat neonatal cardiomyocytes. Eur J Pharmacol. 2002 Jan 18;435(1):73-7.