Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW0J3D)

Drug Name

Ethyl Dihydrogen Phosphate Drug Info

Synonyms

Ethyl dihydrogen phosphate; Monoethyl phosphate; O-Ethyl dihydrogen phosphate; Monoethyl acid phosphate; 1623-14-9; ethylphosphate; Ethyl phosphate, mono-; PHOSPHORIC ACID, MONOETHYL ESTER; UNII-BMH1WT204A; Phosphoric acid monoethyl ester; EINECS 216-603-9; Phosphoric Acid Ethyl Ester; BRN 1702252; BMH1WT204A; AI3-15046; CHEBI:42383; EFS; ethanol-phosphate; mono-ethyl phosphate; ethoxyphosphonic acid; AC1L2LDP; ETHYLPHOSPHORIC ACID; Epitope ID:143619; AC1Q6S7W; SCHEMBL40792; CTK6G4379; Ethyl phosphate ((eto)(ho)2po)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 74190
ChEBI ID: CHEBI:42383
CAS Number: CAS 1623-14-9
TTD Drug ID: DMW0J3D

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hexafluronium bromide	DMFY307	Spasm	MB47.3	Approved	[2]
MEPTAZINOL	DMPSB8F	Pain	MG30-MG3Z	Approved	[3]
Eptastigmine	DMTV7ZM	Cognitive impairment	6D71	Phase 3	[4]
(-)-Phenserine	DMNCY1I	Alzheimer disease	8A20	Phase 3	[5]
Plasma derived human butyrylcholinesterase	DMF3IBC	Neurotoxicity	NE61	Phase 1	[6]
Protexia	DME1Y9W	Alzheimer disease	8A20	Phase 1	[7]
JES-9501	DMYR3IE	Alzheimer disease	8A20	Phase 1	[8]
Tetra-hydro-isoquinoline derivative 3	DMCZA45	N. A.	N. A.	Patented	[9]
Tetra-hydro-isoquinoline derivative 1	DML86IO	N. A.	N. A.	Patented	[9]
Tetra-hydro-isoquinoline derivative 2	DM5CKVF	N. A.	N. A.	Patented	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cholinesterase (BCHE)	TTEB0GD	CHLE_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Synergistic effect of acidosis and succinylcholine-induced hyperkalemia in spinal cord transected rats. Acta Anaesthesiol Scand. 1984 Feb;28(1):87-90.
3	Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation. J Med Chem. 2008 Apr 10;51(7):2027-36.
4	Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J Med Chem. 2006 Apr 6;49(7):2174-85.
5	Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine. Bioorg Med Chem. 2010 Jul 1;18(13):4687-93.
6	Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life. Bioconjug Chem. 2015 Aug 19;26(8):1753-8.
7	In vitro and in vivo characterization of recombinant human butyrylcholinesterase (Protexia) as a potential nerve agent bioscavenger. Chem Biol Interact. 2005 Dec 15;157-158:363-5.
8	Dehydroevodiamine attenuates beta-amyloid peptide-induced amnesia in mice. Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5.
9	A patent review of butyrylcholinesterase inhibitors and reactivators 2010-2017.Expert Opin Ther Pat. 2018 Jun;28(6):455-465.