Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWBV1P)

Drug Name

borneol Drug Info

Synonyms

isoborneol; (+)-borneol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Transient receptor potential cation channel V3 (TRPV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SAR292833	DM63QY0	Pain	MG30-MG3Z	Phase 2	[3]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[4]
diphenylboronic anhydride	DMRQZTS	Discovery agent	N.A.	Investigative	[5]
citral	DM53ZGY	Discovery agent	N.A.	Investigative	[6]
aspirin-triggered resolvin D1	DMOP941	Discovery agent	N.A.	Investigative	[7]
carvacrol	DMINM2D	Discovery agent	N.A.	Investigative	[8]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[9]
diphenyltetrahydrofuran	DMK8T61	Discovery agent	N.A.	Investigative	[5]
carveol	DMGIZ5U	Discovery agent	N.A.	Investigative	[2]
dihydrocarveol	DMS4U68	Discovery agent	N.A.	Investigative	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transient receptor potential cation channel V3 (TRPV3)	TT946IA	TRPV3_HUMAN	Activator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6413).
2	Monoterpenoid agonists of TRPV3. Br J Pharmacol. 2007 Jun;151(4):530-40.
3	Pharmacological profiling of the TRPV3 channel in recombinant and native assays. Br J Pharmacol. 2014 May;171(10):2631-44.
4	2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci. 2004 Jun 2;24(22):5177-82.
5	Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J Biol Chem. 2005 Apr 22;280(16):15928-41.
6	Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One. 2008 May 7;3(5):e2082.
7	17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92.
8	Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci. 2006 May;9(5):628-35.
9	More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci. 2006 Aug;32(4):335-43.