Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWGB40)

Drug Name

(R)-nipecotic acid Drug Info

Synonyms

(R)-piperidine-3-carboxylic acid; 25137-00-2; (R)-(-)-Nipecotic acid; (3R)-piperidine-3-carboxylic acid; (R)-(-)-3-Piperidinecarboxylic acid; (-)-nipecotic acid; (3R)-nipecotic acid; (3R)-(-)-piperidine-3-carboxylic acid; D(-)-Nipecotic acid; r-(-)-3-piperidinecarboxylic acid; 3-Piperidinecarboxylic acid, (R)-; (R)-hexahydronicotinic acid; (R)-(-)-piperidine-3-carboxylic acid; (-)-hexahydronicotinic acid; (3R)-hexahydronicotinic acid; CHEMBL77575; (r)-3-piperidinecarboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 1796510
ChEBI ID: CHEBI:60120
CAS Number: CAS 25137-00-2
TTD Drug ID: DMWGB40

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Gamma-aminobutyric acid uptake (GABAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tiagabine	DMKSQG0	Epilepsy	8A60-8A68	Approved	[3]
NNC 05-2045	DMPZ1EC	N. A.	N. A.	Terminated	[4]
4-substituted 2,4-dioxobutanoic acids	DMELGKY	Discovery agent	N.A.	Investigative	[1]
NNC 711	DM0C8N3	Discovery agent	N.A.	Investigative	[5]
Cis-4-hydroxynipecotic acid	DMX07BG	Discovery agent	N.A.	Investigative	[6]
THPO	DMJD479	Discovery agent	N.A.	Investigative	[7]
------------------------------------------------------------------------------------


⏷ Show the Full List of 6 Drug(s)

Drug(s) Targeting GABA transporter GAT-1 (SLC6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tiagabine	DMKSQG0	Epilepsy	8A60-8A68	Approved	[8]
Metadoxine	DMM4QOJ	Multiple myeloma	2A83	Approved	[9]
GSK683699	DMTW79H	Inflammatory bowel disease	DD72	Phase 2	[2]
CI-966	DM8T2KA	Convulsion	8A68.Z	Phase 1	[10]
NIPECOTIC ACID	DMPV450	Discovery agent	N.A.	Investigative	[11]
2,4-Diamino-butyric acid(GABA)	DMAOGBP	Discovery agent	N.A.	Investigative	[12]
LU32-176B	DM2YOVC	Discovery agent	N.A.	Investigative	[13]
4-Hydroxy-piperidine-3-carboxylic acid	DM9VQ0T	Discovery agent	N.A.	Investigative	[14]
(R/S) EF-1500	DMYDG27	Discovery agent	N.A.	Investigative	[8]
(R)-EF-1520	DM297MU	Discovery agent	N.A.	Investigative	[8]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
GABA transporter GAT-1 (SLC6A1)	TTPRKM0	SC6A1_HUMAN	Inhibitor	[2]
Gamma-aminobutyric acid uptake (GABAU)	TTV9MQG	NOUNIPROTAC	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. Curr Pharm Des. 2000 Aug;6(12):1193-209.
2	Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. J Med Chem. 2004 Nov 4;47(23):5620-9.
3	Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
4	GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology. 2000 Sep;39(12):2399-407.
5	Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):334-41.
6	GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid. Drug Des Deliv. 1987 Sep;2(1):9-21.
7	Anticonvulsant activity of intracerebroventricularly administered glial GABA uptake inhibitors and other GABAmimetics in chemical seizure models. Epilepsy Res. 1989 Jul-Aug;4(1):34-41.
8	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 929).
9	Company report (Alcobra pharma)
10	Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol. 1994 Oct 14;269(2):219-24.
11	Epimeric cis-decahydroquinoline-5-carboxylic acids: effects on gamma-aminobutyric acid uptake and receptor binding in vitro. J Med Chem. 1981 Jul;24(7):788-94.
12	Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions. J Med Chem. 1986 Feb;29(2):224-9.
13	First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anti... J Pharmacol Exp Ther. 2005 Feb;312(2):866-74.
14	Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem. 1982 Oct;25(10):1157-62.