Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWGPO6)

• Drug Name: L-aspartic acid Drug Info
• Synonyms: L-Asp; L-aspartate; Aspatofort

Indication

Disease Entry	ICD 11	Status	REF
Hypokalemia	5C77	Approved	[1]

• Cross-matching ID:
  PubChem CID: 5960
  ChEBI ID: CHEBI:17053
  CAS Number: CAS 56-84-8
  TTD Drug ID: DMWGPO6

Molecule-Related Drug Atlas

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2A (NMDAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[7]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[8]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[9]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[10]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[3]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[11]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[12]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[13]
L-698532	DMO9HM7	Neurological disorder	6B60	Terminated	[14]
L-695902	DMT1DNS	N. A.	N. A.	Terminated	[11]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2D (GluN2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[6]
D-aspartic acid	DM7Z892	Discovery agent	N.A.	Investigative	[6]
[3H]CPP	DMR5UBF	Discovery agent	N.A.	Investigative	[6]
2-Methylamino-succinic acid(NMDA)	DMKP6BM	Discovery agent	N.A.	Investigative	[6]
[3H]MDL105519	DMPKGHB	Discovery agent	N.A.	Investigative	[6]
[3H]CGP39653	DMITR7A	Discovery agent	N.A.	Investigative	[6]
homoquinolinic acid	DMBW5DU	Discovery agent	N.A.	Investigative	[6]
[3H]dizocilpine	DMEC2PF	Discovery agent	N.A.	Investigative	[6]
CGP61594	DM8KFZH	Discovery agent	N.A.	Investigative	[6]
(RS)-(tetrazol-5-yl)glycine	DMYZCRF	Discovery agent	N.A.	Investigative	[6]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 1 (NMDAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cycloserine	DMT1I52	Bacterial infection	1A00-1C4Z	Approved	[15]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[16]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[17]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[8]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[9]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[10]
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[2]
L-698544	DMLRBN1	Alzheimer disease	8A20	Terminated	[11]
DIZOCILPINE	DMMGYXR	Cerebrovascular ischaemia	8B1Z	Terminated	[12]
RPR-104632	DM9L50N	N. A.	N. A.	Terminated	[13]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2C (GluN2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-689560	DMCVY4U	Neurodegenerative disorder	8A20-8A23	Terminated	[5]
D-aspartic acid	DM7Z892	Discovery agent	N.A.	Investigative	[5]
[3H]CPP	DMR5UBF	Discovery agent	N.A.	Investigative	[5]
2-Methylamino-succinic acid(NMDA)	DMKP6BM	Discovery agent	N.A.	Investigative	[5]
[3H]MDL105519	DMPKGHB	Discovery agent	N.A.	Investigative	[5]
[3H]CGP39653	DMITR7A	Discovery agent	N.A.	Investigative	[5]
homoquinolinic acid	DMBW5DU	Discovery agent	N.A.	Investigative	[5]
[3H]dizocilpine	DMEC2PF	Discovery agent	N.A.	Investigative	[5]
CGP61594	DM8KFZH	Discovery agent	N.A.	Investigative	[5]
(RS)-(tetrazol-5-yl)glycine	DMYZCRF	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Glutamate receptor ionotropic NMDA 2B (NMDAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[18]
ELIPRODIL	DMIOGZM	Multiple sclerosis	8A40	Phase 2	[17]
CP-101,606	DMIU19E	Parkinson disease	8A00.0	Phase 2	[19]
CERC-301	DMSABRI	Major depressive disorder	6A70.3	Phase 2	[20]
RGH-896	DMCHZAN	Peripheral neuropathy	8C0Z	Phase 2	[21]
MIJ821	DMN45RI	Major depressive disorder	6A70.3	Phase 2	[22]
NBQX	DMPHZI5	Neurological disorder	6B60	Phase 1	[8]
Neu-2000	DMNJTLC	Cardiac arrest	MC82	Phase 1	[23]
EVT100	DMAKWQD	Major depressive disorder	6A70.3	Phase 1	[24]
YM-90K	DMWRT4L	Convulsion	8A68.Z	Discontinued in Phase 2	[9]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutamate receptor ionotropic NMDA 1 (NMDAR1)	TTLD29N	NMDZ1_HUMAN	Agonist	[2]
Glutamate receptor ionotropic NMDA 2A (NMDAR2A)	TTKJEMQ	NMDE1_HUMAN	Agonist	[3]
Glutamate receptor ionotropic NMDA 2B (NMDAR2B)	TTN9D8E	NMDE2_HUMAN	Agonist	[4]
Glutamate receptor ionotropic NMDA 2C (GluN2C)	TT1M8OW	NMDE3_HUMAN	Agonist	[5]
Glutamate receptor ionotropic NMDA 2D (GluN2D)	TT5POTG	NMDE4_HUMAN	Agonist	[6]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 455).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 456).
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457).
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 458).
• [6] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 459).
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• [8] Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,... J Med Chem. 2001 Sep 13;44(19):3157-65.
• [9] 4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with... Bioorg Med Chem Lett. 2000 May 15;10(10):1133-7.
• [10] Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem. 2010 May 13;53(9):3611-7.
• [11] Amino acid bioisosteres: design of 2-quinolone derivatives as glycine-site N-methyl-D-aspartate receptor antagonists, Bioorg. Med. Chem. Lett. 3(2):299-304 (1993).
• [12] Synthesis and evaluation of 6,11-ethanohexahydrobenzo[b]quinolizidines: a new class of noncompetitive N-methyl-D-aspartate antagonists. J Med Chem. 1995 Jun 23;38(13):2483-9.
• [13] Indeno[1,2-b]pyrazin-2,3-diones: a new class of antagonists at the glycine site of the NMDA receptor with potent in vivo activity. J Med Chem. 2000 Jun 15;43(12):2371-81.
• [14] Synthesis of thieno[2,3-b]pyridinones acting as cytoprotectants and as inhibitors of [3H]glycine binding to the N-methyl-D-aspartate (NMDA) receptor. J Med Chem. 2006 Feb 9;49(3):864-71.
• [15] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [16] Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
• [17] 4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: a novel, potent, and selective NR1/2B NMDA receptor antagonist. J Med Chem. 1999 Jul 29;42(15):2993-3000.
• [18] NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum. PLoS One. 2009;4(4):e5250.
• [19] NMDA receptors as targets for drug action in neuropathic pain. Eur J Pharmacol. 2001 Oct 19;429(1-3):71-8.
• [20] Inhibition of in vivo [(3)H]MK-801 binding by NMDA receptor open channel blockers and GluN2B antagonists in rats and mice. Eur J Pharmacol. 2015 Nov 5;766:1-8.
• [21] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
• [22] Clinical pipeline report, company report or official report of Cadent Therapeutics.
• [23] Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke. Drug News Perspect. 2010 Nov;23(9):549-56.
• [24] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)