Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWV5C3)

Drug Name
[3H]alphabeta-meATP Drug Info
Synonyms
Diphosphomethylphosphonic acid adenosyl ester; alpha,beta-Methylene ATP; alpha,beta-meATP; 7292-42-4; UNII-NYX13NT29D; diphosphomethylphosphonic acid adenosyl ester; alpha,beta-Methyleneadenosine 5'-triphosphate; EINECS 230-723-9; NYX13NT29D; ALPHA,BETA-METHYLENEADENOSINE-5'-TRIPHOSPHATE; CHEMBL132722; CHEBI:35056; 5'-O-(hydroxy{[hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl)adenosine; 5'-(Hydrogen((hydroxy(phosphonooxy)phosphinyl)methyl)phosphonate)adenosine; adenosine 5'-[alpha,beta-methylene]triphosphate; AMP-CPP; Adenosine 5'-(hydrogen; Alpha,Beta-Methyleneadenosine-5'-Triphosphate
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
91557
ChEBI ID
CHEBI:35056
CAS Number
CAS 7292-42-4
TTD Drug ID
DMWV5C3

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Adenylate cyclase (ADCY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ad5-AC6 DMQNFZE Cardiac failure BD10-BD13 Terminated [3]
[3H]cAMP DMZRQU7 Discovery agent N.A. Investigative [2]
N6-CYCLOPENTYLADENOSINE DMD6AJO Discovery agent N.A. Investigative [4]
NSC-88915 DM9WIHJ Solid tumour/cancer 2A00-2F9Z Investigative [5]
2-hydroxy-17beta-estradiol DMM9Z0B Discovery agent N.A. Investigative [5]
2,5-didesoxy-3-ATP DM5CWM0 Discovery agent N.A. Investigative [5]
Adenosine-5'-Rp-Alpha-Thio-Triphosphate DMKY7T8 Discovery agent N.A. Investigative [6]
DEOXYADENOSINE DMS6X1I N. A. N. A. Investigative [7]
NSC-270718 DMUNIWE Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Targeting Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PD-157695 DMDSR1X Schizophrenia 6A20 Preclinical [8]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [2]
[Pterin-6-Yl Methanyl]-Phosphonophosphate DM4ZY79 Discovery agent N.A. Investigative [2]
6-Hydroxymethyl-7,8-Dihydropterin DMYF60K Discovery agent N.A. Investigative [2]
6-Hydroxymethylpterin DM7EWDN Discovery agent N.A. Investigative [6]
P(1)-(6-Hydroxymethylpterin)-P(4)-(5'-adenosyl)tetraphosphate DMOY627 Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Targeting Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [2]
Pyrophosphate 2- DMZQ75M Discovery agent N.A. Investigative [9]
Diphosphate DMHY30B Discovery agent N.A. Investigative [2]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenylate cyclase (ADCY) TT2QM9D NOUNIPROTAC Inhibitor [2]
Bacterial Hydroxymethyl-dihydropterin pyrophosphokinase (Bact folK) TT38ECI HPPK_ECOLI Inhibitor [2]
Bacterial NH(3)-dependent NAD(+) synthetase (Bact nadE) TT8WCXO NADE_ECOLI Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5405).
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758.
4 Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90.
5 Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64.
6 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
7 Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. J Med Chem. 2004 Feb 26;47(5):1207-13.
8 Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J Med Chem. 2001 Apr 26;44(9):1364-71.
9 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.