Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX8LY4)

Drug Name

NS-8 Drug Info

Synonyms

NS-8; 186033-14-7; 2-amino-3-cyano-4-methyl-5-(2-fluorophenyl)pyrrole; 2-amino-5-(2-fluorophenyl)-4-methyl-1H-pyrrole-3-carbonitrile; KVDWOQGDMAEJLM-UHFFFAOYSA-N; CHEMBL42661; SCHEMBL4624842; ZINC21886; MolPort-005-943-258; AKOS027201108; EN300-254366; 2-amino-3-cyano-4-methyl-5-(2fluorophenyl)pyrrole; Z2306534448

Indication

Disease Entry	ICD 11	Status	REF
Urinary incontinence	MF50.2	Phase 1	[1]

Cross-matching ID

PubChem CID: 10176749
TTD Drug ID: DMX8LY4

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Potassium channel unspecific (KC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[3]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[3]
Dronedarone	DMA8FS5	Angina pectoris	BA40	Approved	[4]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[3]
Amifampridine	DMK08L3	LambertEaton myasthenic syndrome	8C62	Approved	[5]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[3]
Pinacidil	DMRADYL	High blood pressure	BA00	Approved	[3]
Dalfampridine	DMM0PDO	Multiple sclerosis	8A40	Approved	[6]
Ibutilide	DMKXY2R	Atrial fibrillation	BC81.3	Approved	[3]
Diazoxide	DML1538	Congenital hyperinsulinism	5A4Y	Approved	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Potassium channel unspecific (KC)	TT1VOHK	NOUNIPROTAC	Agonist	[2]

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References

1	Clinical pipeline report, company report or official report of Nippon Shinyaku Co Ltd.
2	Stimulation of large-conductance calcium-activated potassium channels inhibits neurogenic contraction of human bladder from patients with urinary symptoms and reverses acetic acid-induced bladder hyperactivity in rats. Eur J Pharmacol. 2014 Jul 15;735:68-76.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
5	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.