General Information of Drug (ID: DMY3BMC)

Drug Name
IPH-3102 Drug Info
Synonyms IPH-31XX; TLR-3 receptor agonist (cancer), Innate Pharma; Toll-like receptor 3 agonist (cancer),Innate Pharma
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Terminated [1]
Cross-matching ID
TTD Drug ID
DMY3BMC

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug(s) Targeting Toll-like receptor 3 (TLR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rintatolimod DMYX7VI Human immunodeficiency virus infection 1C62 Phase 3 [3]
Poly-ICLC DM2570B Glioblastoma multiforme 2A00.0 Phase 2 [4]
BCG65-E7 DMAMFXC Anal intraepithelial neoplasia 2E92.5 Discontinued in Phase 3 [5]
polyIC DMV486E Discovery agent N.A. Investigative [6]
Poly IC-poly arginine DMXA4HY Keratosis ED56 Investigative [7]
Anti-TLR3 mabs DMN76A4 Autoimmune diabetes 5A10 Investigative [7]
Poly-ICR DMUMJ7B Keratosis ED56 Investigative [7]
⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 3 (TLR3) TTD24Y0 TLR3_HUMAN Agonist [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037691)
2 Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
3 A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome. PLoS One. 2012;7(3):e31334.
4 Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models. J Transl Med. 2007 Feb 12;5:10.
5 Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia. Gynecol Oncol. 2010 Feb;116(2):208-12.
6 Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8.
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1753).