Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYBX4N)

Drug Name

AZD1390 Drug Info

Synonyms

VQSZIPCGAGVRRP-UHFFFAOYSA-N; SCHEMBL18631972; AZD-1390; EX-A2670; CS-8217; 2089288-03-7; HY-109566

Indication

Disease Entry	ICD 11	Status	REF
Recurrent glioblastoma	2A00.00	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting ATM serine/threonine kinase (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
M3541	DMG98QO	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
AZD0156	DMWCJEU	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
KU-60019	DMWA5XP	Non-small-cell lung cancer	2C25.Y	Clinical trial	[2]
CGK733	DM8OAN9	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ATM serine/threonine kinase (ATM)	TTKBM7V	ATM_HUMAN	Inhibitor	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8(10):2894-902.
3	Small molecule-based reversible reprogramming of cellular lifespan. Nat Chem Biol. 2006 Jul;2(7):369-74.