Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYHK3Y)

• Drug Name: BIO-017 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Angelman syndrome	LD90.0	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMYHK3Y

Molecule-Related Drug Atlas

Drug(s) Targeting Transient receptor potential cation channel V1 (TRPV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[2]
CNTX-4975	DMB4JPG	Knee osteoarthritis	FA01	Phase 3	[3]
XEN-D0501	DMG7PDY	Overactive bladder	GC50.0	Phase 2	[4]
Resiniferatoxin	DMP62L5	Neuropathic pain	8E43.0	Phase 2	[5]
PAC-14028	DM3816P	Atopic dermatitis	EA80	Phase 2	[6]
GRC-15300	DMWXJSZ	Pain	MG30-MG3Z	Phase 2	[7]
DWP-05195	DMQKU2F	Neuropathic pain	8E43.0	Phase 2	[8]
SB-705498	DMRYHWI	Rhinitis	FA20	Phase 2	[9]
GRC-6211	DMZ0D3V	Asthma	CA23	Phase 1	[10]
ABT-102	DMJFWPR	Chronic pain	MG30	Phase 1	[9]

Drug(s) Targeting G-protein coupled receptor 55 (GPR55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[11]
N-oleoylethanolamide	DMJQ4L7	Discovery agent	N.A.	Investigative	[11]
[3H]CP55940	DMU7FC5	Discovery agent	N.A.	Investigative	[11]
lysophosphatidylinositol	DMETM3R	Discovery agent	N.A.	Investigative	[12]
O-1602	DM9VISB	Discovery agent	N.A.	Investigative	[13]
abnormal cannabidiol	DMV6DAO	Discovery agent	N.A.	Investigative	[11]
O-arachidonoyl ethanolamine	DML0P72	Discovery agent	N.A.	Investigative	[11]
CID1172084	DMK6YOP	Discovery agent	N.A.	Investigative	[14]
CID16020046	DMLWZRT	Discovery agent	N.A.	Investigative	[15]
2-arachidonyl glyceryl ether	DM2H8TV	Discovery agent	N.A.	Investigative	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
G-protein coupled receptor 55 (GPR55)	TTNET8J	GPR55_HUMAN	Modulator	[1]
Transient receptor potential cation channel V1 (TRPV1)	TTMI6F5	TRPV1_HUMAN	Agonist	[1]

References

• [1] Clinical pipeline report, company report or official report of Biom Therapeutics
• [2] Capsaicin receptor: TRPV1 a promiscuous TRP channel. Handb Exp Pharmacol. 2007;(179):155-71.
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. Br J Clin Pharmacol. 2011 Dec;72(6):921-31.
• [5] Emerging drugs in neuropathic pain. Expert Opin Emerg Drugs. 2007 Mar;12(1):113-26.
• [6] Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases. Arch Pharm Res. 2012 Mar;35(3):393-6.
• [7] The discovery and development of analgesics: new mechanisms, new modalities. J Clin Invest. 2010 November 1; 120(11): 3753-3759.
• [8] TRPV1 Antagonists as Analgesic Agents. The Open Pain Journal, 2013, 6, (Suppl 1: M11), 108-118 .
• [9] Analgesic potential of TRPV1 antagonists. Biochem Pharmacol. 2009 Aug 1;78(3):211-6.
• [10] GRC-6211, a new oral specific TRPV1 antagonist, decreases bladder overactivity and noxious bladder input in cystitis animal models. J Urol. 2009 Jan;181(1):379-86.
• [11] The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol. 2007 Dec;152(7):1092-101.
• [12] Screening beta-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. J Biomol Screen. 2013 Jun;18(5):599-609.
• [13] International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB and CB Pharmacol Rev. 2010 Dec;62(4):588-631.
• [14] Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2011 Jun 28;50(25):5633-47.
• [15] A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. J Pharmacol Exp Ther. 2013 Jul;346(1):54-66.