Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYK6OU)

Drug Name

RQ-00310941 Drug Info

Synonyms

RQ-00202065; 5-HT 2b antagonists (oral, IBS), RaQualia; 5-HT 2b antagonists (oral, irritable bowel syndrome), RaQualia

Indication

Disease Entry	ICD 11	Status	REF
Irritable bowel syndrome	DD91.0	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting 5-HT 2B receptor (HTR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[2]
Triflupromazine	DMKFQJP	Nausea	MD90	Approved	[3]
Minaprine	DM0EP7M	Depression	6A70-6A7Z	Approved	[4]
SPN-812	DMTV7XH	Attention deficit hyperactivity disorder	6A05.Z	Phase 4	[5]
Vabicaserin	DM9GZW6	Psychotic disorder	6A20-6A25	Phase 2	[6]
PRX-08066	DMR7H2V	Pulmonary arterial hypertension	BB01.0	Phase 2	[7]
Pyrimidine derivative 29	DMVOYJ8	N. A.	N. A.	Patented	[8]
Pyrimidine derivative 26	DM90WKN	N. A.	N. A.	Patented	[8]
Pyrimidine derivative 23	DM5MLQU	N. A.	N. A.	Patented	[8]
Pyrimidine derivative 25	DM51MFS	N. A.	N. A.	Patented	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 7).
2	Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23.
3	Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat. Br J Pharmacol. 1979 Sep;67(1):79-85.
4	Privileged structures: a useful concept for the rational design of new lead drug candidates. Mini Rev Med Chem. 2007 Nov;7(11):1108-19.
5	New Insights into the Mechanism of Action of Viloxazine: Serotonin and Norepinephrine Modulating Properties. J Exp Pharmacol. 2020 Aug 25;12:285-300.
6	Prediction of Efficacy of Vabicaserin, a 5-HT2C Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model.CPT Pharmacometrics Syst Pharmacol.2014 Apr 23;3:e111.
7	Emerging treatments for pulmonary arterial hypertension. Expert Opin Emerg Drugs. 2006 Nov;11(4):609-19.
8	Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014).Expert Opin Ther Pat. 2016;26(1):89-106.