Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYP3KI)

Drug Name
SINOMENINE Drug Info
Synonyms Cucoline; Kukoline; (9alpha,13alpha,14alpha)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one
Indication
Disease Entry ICD 11 Status REF
Arthritis FA20 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
5459308
ChEBI ID
CHEBI:9163
CAS Number
CAS 115-53-7
TTD Drug ID
DMYP3KI

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting NADPH oxidase (NOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
GKT-137831 DMOVB3Y Fibrosis GA14-GC01 Phase 2 [3]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
NADPH oxidase (NOX) TTFQVUT NOUNIPROTAC Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008290)
2 Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J Neuroinflammation. 2007 Sep 19;4:23.
3 Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NOX) in Experimental Liver Fibrosis: GKT137831 as a Novel Potential Therapeutic Agent. Hepatology. 2012 December; 56(6): 2316-2327.