Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYSG9J)

Drug Name

Chemosensitizers Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Multidrug resistance protein (MDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzquinamide	DMU4D5Y	Nausea	MD90	Approved	[2]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[3]
Ortataxel	DM1EK5D	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
MM36	DM6VPIO	Atopic dermatitis	EA80	Phase 2	[3]
Valspodar	DMXRU9M	Acute myeloid leukaemia	2A60	Discontinued in Phase 3	[5]
WK-X-34	DMX0ZBC	Discovery agent	N.A.	Investigative	[3]
KP772	DMUZSJ2	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Multidrug resistance protein (MDR)	TT0JLSD	NOUNIPROTAC	Inhibitor	[1]

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References

1	P-glycoprotein as a drug target in the treatment of multidrug resistant cancer. Curr Drug Targets. 2000 Jul;1(1):85-99.
2	Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells. Oncol Res. 1992;4(8-9):359-65.
3	Thiazolides: a new class of antiviral drugs. Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):667-74.
4	Clinical pipeline report, company report or official report of Spectrum Phamaceuticals (2009).
5	Intracellular levels of two cyclosporin derivatives valspodar (PSC 833) and cyclosporin a closely associated with multidrug resistance-modulating activity in sublines of human colorectal adenocarcinoma HCT-15. Jpn J Cancer Res. 2001 Oct;92(10):1116-26.