Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYSQHT)

Drug Name
XL-041 Drug Info
Synonyms
XCT-0179628; XCT-628; XL-652; XL-652); LXR modulator, X-Ceptor Therapeutics; LXR modulators, Exelixis/Sankyo; Liver X receptormodulator, Exelixis/Sankyo; Liver X receptor modulator, X-Ceptor; LXR agonist (atherosclerosis), BMS/Exelixis; LXR modulators, X-Ceptor Therapeutics/Sankyo; Liver X receptor modulator, X-Ceptor Therapeutics/Sankyo; Liver X receptor modulators (cardiovascular disorders), Exelixis/Bristol-Myers Squibb
Indication
Disease Entry ICD 11 Status REF
Arteriosclerosis BD40 Phase 1 [1]
Cross-matching ID
PubChem CID
49787490
TTD Drug ID
DMYSQHT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Oxysterols receptor LXR (NR1H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ALX-101 DMCAFXM Atopic dermatitis EA80 Phase 2 [3]
RGX-104 DM5AIKR Non-small-cell lung cancer 2C25.Y Phase 1/2 [4]
BMS-779788 DMKR8S1 Arteriosclerosis BD40 Phase 1 [5]
CS-8080 DMRH740 Arteriosclerosis BD40 Phase 1 [5]
BMS-852927 DMZS1D2 Arteriosclerosis BD40 Phase 1 [5]
XL652/XL014 DM89NML Cardiovascular disease BA00-BE2Z Phase 1 [6]
LXR 623 DM3OP41 Arteriosclerosis BD40 Phase 1 [5]
T0901317 DMZQVDI Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Oxysterols receptor LXR (NR1H) TTM1EQF NOUNIPROTAC Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029634)
2 Emerging small molecule drugs. Handb Exp Pharmacol. 2015;224:617-30.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Liver X receptors in lipid metabolism: opportunities for drug discovery. Nat Rev Drug Discov. 2014 Jun;13(6):433-44.
6 Clinical pipeline report, company report or official report of Exelixis (2011).
7 The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003 Nov;44(11):2039-48.