Details of the Drug

General Information of Drug (ID: DMZQVDI)

Drug Name
T0901317
Synonyms
T0901317; 293754-55-9; T 0901317; TO-901317; TO901317; UNII-A07663A39I; T-0901317; CHEMBL62136; N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide; A07663A39I; N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE; N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzenesulfonamide; T-1317
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 1 Molecular Weight (mw) 481.3
Logarithm of the Partition Coefficient (xlogp) 4.9
Rotatable Bond Count (rotbonds) 5
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 13
Chemical Identifiers
Formula
C17H12F9NO3S
IUPAC Name
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
Canonical SMILES
C1=CC=C(C=C1)S(=O)(=O)N(CC(F)(F)F)C2=CC=C(C=C2)C(C(F)(F)F)(C(F)(F)F)O
InChI
InChI=1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2
InChIKey
SGIWFELWJPNFDH-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
447912
CAS Number
293754-55-9
UNII
A07663A39I
DrugBank ID
DB07080
TTD ID
D0B5FC

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Oxysterols receptor LXR (NR1H) TTM1EQF NOUNIPROTAC Binder [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3) OTR4990X PLPL3_HUMAN Gene/Protein Processing [3]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [4]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Gene/Protein Processing [5]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Gene/Protein Processing [6]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Gene/Protein Processing [4]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Gene/Protein Processing [7]
ATP-binding cassette sub-family G member 1 (ABCG1) OT5BG6MK ABCG1_HUMAN Gene/Protein Processing [8]
ATP-citrate synthase (ACLY) OTRL9ZRP ACLY_HUMAN Gene/Protein Processing [9]
Cholesteryl ester transfer protein (CETP) OTAGPPOE CETP_HUMAN Gene/Protein Processing [10]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Experimental Cancer Drug Sensitivity Information

Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Bone Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
RPMI-3460/CS1 GDSC1 5.5913 7.416 2.7528 0.6809
ES1 GDSC1 -0.1632 10.7104 -3.5491 47.6975
NOS-1 [Human HNSCC] GDSC1 2.8856 11.2804 -1.0046 29.9042
TC-71 GDSC1 4.1837 7.3334 2.0079 7.9464
HuO9 GDSC1 4.3858 6.6536 2.4661 4.0477
SK-ES-1 GDSC1 4.3995 7.631 2.0133 7.316
EW-18 GDSC1 4.4861 7.1401 2.3025 4.9904
SK-PN-DW GDSC1 4.5384 8.3933 1.7417 8.9175
A-673 GDSC1 4.5631 7.1508 2.3455 4.5083
CADO-ES1 GDSC1 4.5865 7.8962 2.0114 6.8487
EW-24 GDSC1 4.5942 7.9622 1.9852 7.0186
MHH-ES-1 GDSC1 4.8035 6.824 2.6281 2.164
CHSA0108 GDSC1 4.9673 7.6737 2.3462 3.678
U2OS GDSC1 5.1068 8.2281 2.1781 4.5253
EW-1 GDSC1 5.1472 7.8529 2.3666 3.2253
MG-63 GDSC1 5.1833 6.5053 2.9248 0.3525
HOS GDSC1 5.213 6.8703 2.8018 0.7717
CHSA8926 GDSC1 5.2896 8.3935 2.2078 3.9874
SJSA-1 GDSC1 5.3736 7.5373 2.6121 1.4919
EW-16 GDSC1 5.455 9.3032 1.8961 5.7034
ES6 GDSC1 5.5432 7.7054 2.6221 1.2649
ES8 GDSC1 5.5889 7.2057 2.8286 0.4321
CAL-78 GDSC1 5.6399 7.4098 2.7745 0.5745
ES7 GDSC1 5.6729 9.8753 1.765 6.1234
ES5 GDSC1 5.6779 8.9134 2.1907 3.4412
EW-7 GDSC1 5.7708 7.3305 2.8524 0.2909
CAL-72 GDSC1 5.7722 7.4143 2.8235 0.3613
HuO-3N1 GDSC1 5.8552 8.3822 2.4953 1.5484
SaOS-2 GDSC1 5.8734 7.625 2.7868 0.415
CHSA0011 GDSC1 6.1955 8.7422 2.5038 1.1983
EW-11 GDSC1 6.2598 8.4886 2.6245 0.7041
EW-13 GDSC1 6.2681 14.8456 -0.1806 16.0483
H-EMC-SS GDSC1 6.4517 8.5438 2.6779 0.4522
G-292 clone A141B1 GDSC1 6.5492 13.7722 0.5077 11.8502
NY GDSC1 6.6938 8.7629 2.6899 0.3352
ES4 GDSC1 6.7336 8.6135 2.7549 0.2044
EW-3 GDSC1 6.7629 8.8119 2.6978 0.2981
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 146 Cell Line(s) in Haematopoietic And Lymphoid Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
JM1 GDSC1 -1.7527 1.3491 -1.8265 62.187
OCI-M1 GDSC1 -7.838 23.5076 -17.0885 62.2712
Karpas-231 GDSC1 -6.3905 9.5694 -9.4449 68.4093
P30/OHK GDSC1 -5.4572 -0.685 -5.531 86.2574
BL-41 GDSC1 -5.192 -0.338 -5.2823 84.6434
MY-M12 GDSC1 -2.2388 4.9053 -3.2334 60.7683
SU-DHL-8 GDSC1 -1.4068 25.3514 -11.8256 51.5518
MOLT-13 GDSC1 0.8817 52.9557 -23.5347 48.3951
SUP-M2 GDSC1 2.0601 7.4008 0.1731 28.3599
SIG-M5 GDSC1 2.2529 3.1753 2.1962 14.1568
MV4-11 GDSC1 2.37 7.0199 0.6492 24.2659
Ku812 GDSC1 2.6184 3.7102 2.4327 10.4905
RS4;11 GDSC1 2.658 17.5547 -4.333 38.3762
SU-DHL-16 GDSC1 2.7587 12.7555 -1.8503 33.0738
BC-1 GDSC1 2.769 4.1245 2.416 9.8572
LC4-1 GDSC1 2.8306 12.8411 -1.8311 32.7623
ALL-PO GDSC1 2.8494 4.2458 2.4412 9.2884
Sc-1 GDSC1 2.8757 5.3173 1.9511 12.9375
MOLP-8 GDSC1 2.9288 7.3777 0.979 19.7608
NKM-1 GDSC1 3.12 4.9404 2.3596 8.7579
NALM-6 GDSC1 3.1725 6.8576 1.4502 15.5127
EB2 GDSC1 3.1963 9.1691 0.3154 22.7179
ST486 GDSC1 3.2082 4.2841 2.7638 5.2366
GDM-1 GDSC1 3.3139 17.0113 -3.5066 35.1015
SUP-B15 GDSC1 3.3146 6.957 1.521 14.4543
KOPN-8 GDSC1 3.3174 5.219 2.3922 7.7426
MOLM-13 GDSC1 3.321 10.4067 -0.1984 24.8877
KMS-12-BM GDSC1 3.3228 5.8603 2.0762 10.2016
CTB-1 GDSC1 3.3587 15.0277 -2.4775 32.7105
NOMO-1 GDSC1 3.4184 7.18 1.4958 14.2556
CESS GDSC1 3.4193 5.3737 2.3995 7.3177
K-562 GDSC1 3.4198 5.3601 2.4067 7.2597
P32/ISH GDSC1 3.4211 4.741 2.7171 4.8099
SUP-HD1 GDSC1 3.4553 4.9035 2.6635 5.1142
LP-1 GDSC1 3.4554 5.5913 2.3202 7.8148
THP-1 GDSC1 3.5019 5.201 2.5522 5.8313
Ramos.2G6.4C10 GDSC1 3.5098 5.9853 2.1673 8.8242
HL-60 GDSC1 3.5109 5.0692 2.6249 5.2306
ML-2 GDSC1 3.5352 6.1281 2.1164 9.1339
KCL-22 GDSC1 3.5495 7.4221 1.482 13.8852
EoL-1 GDSC1 3.5563 5.6342 2.3793 7.0067
JSC-1 GDSC1 3.5604 5.929 2.2357 8.1171
KMOE-2 GDSC1 3.5703 6.3624 2.0275 9.7035
JJN-3 GDSC1 3.6022 6.2679 2.0999 9.035
HAL-01 GDSC1 3.6198 5.545 2.4729 6.0662
SU-DHL-6 GDSC1 3.6793 5.6776 2.4525 6.0376
SU-DHL-10 GDSC1 3.6808 5.0502 2.7621 3.6318
P31/FUJ GDSC1 3.765 5.6224 2.543 5.0747
ARH-77 GDSC1 3.7906 5.3248 2.7062 3.7497
QIMR-WIL GDSC1 3.8064 8.2294 1.2839 14.4083
KG-1 GDSC1 3.8317 6.3638 2.228 7.3073
SK-MM-2 GDSC1 3.848 6.2014 2.3197 6.5514
ALL-SIL GDSC1 3.8694 6.0491 2.4097 5.7957
EM-2 GDSC1 3.8705 6.8879 1.9985 8.9482
Reh GDSC1 3.8749 5.4976 2.6808 3.7143
OCI-AML-2 GDSC1 3.8781 7.0765 1.911 9.5889
PL-21 GDSC1 3.8869 7.3894 1.7629 10.6753
697 GDSC1 3.8937 7.1069 1.9077 9.5649
MOLT-16 GDSC1 3.9134 5.8748 2.5256 4.7854
LAMA-84 GDSC1 3.916 6.7523 2.0991 8.0404
BALL-1 GDSC1 3.9201 5.506 2.7071 3.4008
BV-173 GDSC1 3.9349 6.726 2.1259 7.7786
YT GDSC1 3.9659 5.4061 2.7839 2.7239
HC-1 GDSC1 3.9706 5.4566 2.7631 2.8636
Namalwa GDSC1 3.9724 6.4723 2.277 6.5145
WIL2 NS GDSC1 3.9815 7.865 1.5992 11.5827
OCI-AML-3 GDSC1 3.9966 6.4803 2.2903 6.3435
HEL GDSC1 4.0115 6.2117 2.4307 5.2367
Mono-Mac-6 GDSC1 4.0118 10.6345 0.2479 20.1655
VL51 GDSC1 4.0125 6.1947 2.4396 5.167
Daudi GDSC1 4.0147 7.0827 2.0092 8.4271
L-363 GDSC1 4.0412 5.8242 2.6357 3.6269
Granta-519 GDSC1 4.0467 6.7787 2.1806 7.0346
AMO1 GDSC1 4.0654 6.6511 2.2557 6.4128
BE-13 GDSC1 4.0748 7.2123 1.9892 8.4003
RPMI-8226 GDSC1 4.0774 6.8037 2.1902 6.8753
A4/Fukuda GDSC1 4.0893 5.9263 2.6186 3.6352
RPMI-8866 GDSC1 4.0918 8.5413 1.3482 13.0266
SU-DHL-1 GDSC1 4.1306 7.3359 1.9689 8.3898
JVM-3 GDSC1 4.1366 6.1545 2.5417 4.0851
MEG-01 GDSC1 4.1537 7.1549 2.0734 7.5404
SU-DHL-5 GDSC1 4.1545 5.3025 2.9402 1.2824
SCC-3 GDSC1 4.2836 7.6991 1.9006 8.4618
RPMI-6666 GDSC1 4.3088 11.6637 -0.0329 20.6816
Kasumi-1 GDSC1 4.323 8.565 1.507 11.2023
MOLT-4 GDSC1 4.3329 5.8271 2.8084 1.8134
CA46 GDSC1 4.3486 6.6285 2.4546 4.2148
HH [Human lymphoma] GDSC1 4.3677 15.0395 -1.6654 27.2671
TUR GDSC1 4.3736 10.4242 0.6301 16.8058
CTV-1 GDSC1 4.4065 6.3558 2.6149 2.9605
Karpas-620 GDSC1 4.4247 9.5094 1.1182 13.5677
H9 GDSC1 4.4328 11.3338 0.2252 18.934
OPM-2 GDSC1 4.4509 6.3959 2.6226 2.8202
MC116 GDSC1 4.4523 5.7329 2.9093 1.0339
WSU-DLCL2 GDSC1 4.4569 10.0633 0.8699 15.0758
DEL GDSC1 4.4573 8.2384 1.7606 9.002
Farage GDSC1 4.4858 6.0532 2.792 1.6644
DG-75 GDSC1 4.4867 7.8413 1.9714 7.3933
Raji GDSC1 4.4994 9.2014 1.3228 11.9693
L-428 GDSC1 4.5101 7.888 1.9648 7.3808
JURL-MK1 GDSC1 4.5309 6.9828 2.4032 4.1719
WSU-NHL GDSC1 4.5311 6.3866 2.6718 2.3445
SUP-T1 GDSC1 4.571 8.9369 1.5019 10.5272
KM-H2 GDSC1 4.5912 7.3118 2.2883 4.8502
Karpas-299 GDSC1 4.5967 7.2304 2.3293 4.5479
Loucy GDSC1 4.6022 7.8798 2.0294 6.6802
JVM-2 GDSC1 4.6114 8.1006 1.9308 7.3669
U266B1 GDSC1 4.6204 6.3862 2.7198 1.8931
OCI-Ly19 GDSC1 4.6851 6.579 2.6711 2.0892
Jiyoye GDSC1 4.6987 8.6972 1.7046 8.7563
OCI-AML-5 GDSC1 4.7039 15.7101 -1.7368 26.5351
ATN-1 GDSC1 4.7308 7.8378 2.131 5.6478
RL GDSC1 4.739 7.2398 2.4098 3.6928
NU-DUL-1 GDSC1 4.7521 9.1477 1.5249 9.8734
GR-ST GDSC1 4.7612 9.9107 1.1631 12.2969
ROS-50 GDSC1 4.7632 7.5007 2.3059 4.3539
DB GDSC1 4.7818 9.0072 1.6123 9.1884
KY821 GDSC1 4.8046 6.5726 2.7345 1.5382
CCRF-CEM GDSC1 4.8056 10.4968 0.9098 13.8018
BC-3 GDSC1 4.8475 10.0224 1.1691 12.0185
TK [Human B-cell lymphoma] GDSC1 4.8812 6.3246 2.8694 0.7685
RC-K8 GDSC1 4.9287 7.1391 2.5587 2.3903
KE-37 GDSC1 4.9554 17.0516 -2.2087 27.3365
SU-DHL-4 GDSC1 4.9635 6.5377 2.8225 0.903
A3/Kawakami GDSC1 5.0623 18.1123 -2.6527 28.3277
SR GDSC1 5.0637 20.5881 -3.8814 31.2618
Hs 445 GDSC1 5.0865 6.6595 2.8287 0.7646
KMS-11 GDSC1 5.1421 9.6161 1.56 8.6453
L-540 GDSC1 5.1526 11.3774 0.726 13.971
HT GDSC1 5.1689 9.654 1.5594 8.5854
ME1 GDSC1 5.2018 6.2789 3.0107 0.1403
MHH-PREB-1 GDSC1 5.2165 6.9564 2.7703 0.9023
EJM GDSC1 5.2748 7.4575 2.5981 1.68
Karpas-422 GDSC1 5.3732 7.0005 2.8189 0.5886
L-1236 GDSC1 5.4035 7.5276 2.6296 1.3721
MN-60 GDSC1 5.5372 14.7177 -0.6254 19.9505
HDLM-2 GDSC1 5.5587 7.8728 2.563 1.5323
U-698-M GDSC1 5.6487 7.8907 2.5963 1.2816
MLMA GDSC1 5.8284 7.6781 2.7506 0.5437
P12-Ichikawa GDSC1 5.9293 14.8409 -0.409 17.9601
RPMI-8402 GDSC1 6.0371 16.8067 -1.2869 21.4081
DND-41 GDSC1 6.0925 13.8199 0.1914 14.5868
NB4 GDSC1 6.2661 19.3916 -2.3847 24.617
Karpas-45 GDSC1 6.2824 18.3166 -1.8478 22.8485
PF-382 GDSC1 6.7802 17.4348 -1.0746 18.8257
VAL GDSC1 7.1914 24.1496 -4.0434 26.9984
⏷ Show the Full List of 146 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 11 Cell Line(s) in Aero Dig Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OACM5.1 C GDSC1 3.4999 5.4889 2.4071 6.9786
KYSE-50 GDSC1 3.6907 5.1754 2.708 4.0197
KYAE-1 GDSC1 3.7998 5.3311 2.7095 3.6998
TE-12 GDSC1 4.5332 7.5432 2.1435 6.0255
ESO-51 GDSC1 4.9209 7.2866 2.4908 2.8257
ESO-26 GDSC1 5.4293 6.9961 2.8427 0.474
HCE-4 GDSC1 5.4646 7.7168 2.5821 1.5409
FLO-1 GDSC1 5.5718 8.6826 2.234 3.3472
SK-GT-4 GDSC1 5.7248 9.1945 2.0946 3.9479
KYSE-220 GDSC1 6.1666 8.1955 2.6944 0.5373
OACP4 C GDSC1 6.3869 8.1099 2.8044 0.2034
⏷ Show the Full List of 11 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Ascites Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
COLO 684 GDSC1 3.7437 5.906 2.3881 6.3385
Cancer Drug Sensitivity Data Curated from 31 Cell Line(s) in Autonomic Ganglia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-N-MC-IXC GDSC1 2.9772 3.9524 2.7038 6.7048
SJNB-12 GDSC1 3.3632 5.0987 2.4907 6.7994
Kelly GDSC1 3.4521 4.6965 2.7642 4.3328
SJNB-13 GDSC1 3.4917 4.7989 2.7444 4.3556
NB1 GDSC1 3.7048 5.5 2.5591 5.1305
SJNB-17 GDSC1 3.7674 15.2866 -2.2699 30.9007
SK-N-BE(2)-M17 GDSC1 3.9919 6.996 2.0351 8.2993
SK-N-DZ GDSC1 4.0523 6.7851 2.1814 7.0126
SJNB-7 GDSC1 4.1556 6.4295 2.4238 4.9093
CHP-126 GDSC1 4.2322 7.0361 2.1851 6.4883
TGW GDSC1 4.2895 8.1396 1.6906 9.9834
SK-N-AS GDSC1 4.4713 8.1779 1.7994 8.6833
KP-N-YN GDSC1 4.5287 7.0352 2.3777 4.3564
SiMa GDSC1 4.7045 7.0751 2.4638 3.3961
CHP-134 GDSC1 4.7068 6.233 2.8267 1.1608
KP-N-YS GDSC1 4.7106 7.7009 2.182 5.3336
GOTO GDSC1 4.7538 7.1529 2.4572 3.3454
GI-ME-N GDSC1 4.7994 10.3264 0.9883 13.3229
SJNB-10 GDSC1 4.827 6.718 2.685 1.7901
CHP-212 GDSC1 4.8757 6.6823 2.7239 1.5034
SJNB-14 GDSC1 4.9907 6.9905 2.6527 1.7468
IMR-5 GDSC1 5.0476 7.0781 2.6443 1.7176
SJNB-5 GDSC1 5.1456 9.5575 1.5898 8.436
NB69 GDSC1 5.2491 7.2749 2.6598 1.3911
NB(TU)1 GDSC1 5.3815 6.9033 2.8577 0.453
SJNB-6 GDSC1 5.4897 6.8851 2.905 0.2712
SK-N-FI GDSC1 5.4962 7.3716 2.7304 0.8357
LA-N-6 GDSC1 5.5247 7.6009 2.6547 1.1337
SK-N-SH GDSC1 5.6856 7.9314 2.5966 1.2448
MHH-NB-11 GDSC1 5.7566 7.6762 2.723 0.6781
NH-12 GDSC1 5.9987 8.0566 2.6795 0.6768
⏷ Show the Full List of 31 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Biliary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuCC-T1 GDSC1 5.5154 7.1007 2.8382 0.4413
Cancer Drug Sensitivity Data Curated from 50 Cell Line(s) in Breast Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
OCUB-M GDSC1 3.662 5.9891 2.2851 7.3974
COLO 824 GDSC1 3.8468 5.7751 2.5272 4.9597
HCC2218 GDSC1 3.9563 7.4096 1.8053 10.1395
HCC2157 GDSC1 4.1204 6.3052 2.4596 4.7325
CAMA-1 GDSC1 4.1782 6.4913 2.4094 4.9587
MDA-MB-468 GDSC1 4.2635 6.5451 2.4396 4.5249
HCC1599 GDSC1 4.2816 6.6593 2.3975 4.7889
JIMT-1 GDSC1 4.3039 6.3079 2.5754 3.4527
HCC1500 GDSC1 4.4081 9.5958 1.0637 13.9772
CAL-148 GDSC1 4.5361 6.3736 2.6802 2.2813
Evsa-T GDSC1 4.5639 7.3825 2.2384 5.269
HCC1187 GDSC1 4.638 8.2344 1.8848 7.6301
DU4475 GDSC1 4.6611 6.0971 2.8602 1.0402
MDA-MB-415 GDSC1 4.7261 7.3958 2.3316 4.2538
CAL-120 GDSC1 4.7665 5.9954 2.9464 0.5402
ZR-75-30 GDSC1 4.7872 8.0492 2.068 5.9636
MDA-MB-453 GDSC1 4.794 7.9535 2.1166 5.6054
HDQ-P1 GDSC1 4.8 6.7552 2.6556 2.0035
MDA-MB-231 GDSC1 4.8032 7.1967 2.4656 3.1972
BT-483 GDSC1 4.8177 6.6794 2.6965 1.7365
CAL-51 GDSC1 4.8444 7.4743 2.3653 3.7856
BT-20 GDSC1 4.9478 6.5525 2.8097 0.9783
BT-474 GDSC1 5.0735 6.3212 2.9489 0.3367
UACC-812 GDSC1 5.088 7.0326 2.6823 1.4621
MDA-MB-361 GDSC1 5.1618 9.3692 1.6881 7.7308
CAL-85-1 GDSC1 5.2097 7.7801 2.4311 2.7246
MDA-MB-436 GDSC1 5.2235 7.0703 2.7292 1.0815
HCC1428 GDSC1 5.2742 7.8295 2.4434 2.5524
MDA-MB-175-VII GDSC1 5.2748 7.2703 2.6733 1.2956
MFM-223 GDSC1 5.2958 8.275 2.2632 3.6234
HCC1419 GDSC1 5.338 7.0678 2.7793 0.7634
AU565 GDSC1 5.4142 7.9106 2.4794 2.1474
HCC1954 GDSC1 5.4718 7.5631 2.6462 1.2232
T-47D GDSC1 5.4903 9.8676 1.6603 7.1826
BT-549 GDSC1 5.4956 8.444 2.2963 3.092
HCC38 GDSC1 5.5344 7.7953 2.5827 1.4618
UACC-893 GDSC1 5.5426 8.1171 2.4567 2.1048
MDA-MB-157 GDSC1 5.5846 7.6894 2.6465 1.1155
HCC70 GDSC1 5.6546 7.5583 2.7256 0.7372
EFM-192A GDSC1 5.6729 7.4761 2.7632 0.5923
MRK-nu-1 GDSC1 5.6985 7.0972 2.9069 0.1983
HCC1395 GDSC1 5.7202 8.1822 2.5135 1.6016
MCF-7 GDSC1 5.7577 7.4994 2.7878 0.4676
Hs 578T GDSC1 5.7702 8.0026 2.6058 1.1279
YMB-1-E GDSC1 5.7772 9.1403 2.1454 3.5567
MDA-MB-330 GDSC1 5.7873 8.007 2.6114 1.0893
HCC1937 GDSC1 5.8912 7.8706 2.7051 0.6556
HCC1806 GDSC1 5.941 10.6259 1.5825 6.7562
EFM-19 GDSC1 6.0457 7.7828 2.7951 0.3238
HCC1569 GDSC1 6.5733 8.8543 2.6134 0.572
⏷ Show the Full List of 50 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 54 Cell Line(s) in Central Nervous System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Daoy GDSC1 -6.4274 1.652 -6.9086 81.0544
GaMG GDSC1 3.7892 5.0961 2.8152 2.9295
D-423MG GDSC1 3.7989 6.561 2.1061 8.3482
U-251MG GDSC1 3.8818 5.9211 2.481 5.2142
Becker GDSC1 3.938 5.9696 2.4968 4.937
D-247MG GDSC1 4.1811 6.4287 2.441 4.7169
SF295 GDSC1 4.242 6.3552 2.5149 4.0273
D-336MG GDSC1 4.3247 7.302 2.1204 6.7236
D-566MG GDSC1 4.4014 8.1397 1.7695 9.0926
Hs 683 GDSC1 4.4569 7.1357 2.286 5.1781
8-MG-BA GDSC1 4.4675 6.0212 2.7961 1.668
LNZTA3WT4 GDSC1 4.5568 7.6475 2.1096 6.2126
AM-38 GDSC1 4.5799 7.077 2.3896 4.1609
YKG-1 GDSC1 4.6536 6.3111 2.7686 1.5531
LN-18 GDSC1 4.6569 5.7742 2.9844 0.4742
H4 GDSC1 4.726 7.6173 2.2301 4.9609
D-542MG GDSC1 4.7377 6.7852 2.61 2.3829
A-172 GDSC1 4.7464 6.8684 2.5786 2.5671
U-118MG GDSC1 4.7464 6.4508 2.7564 1.4937
D-263MG GDSC1 4.7621 6.7125 2.6542 2.0707
D283 Med GDSC1 4.78 7.907 2.1295 5.5463
MOG-G-CCM GDSC1 4.7802 9.5591 1.3462 11.0217
42-MG-BA GDSC1 4.7897 8.2451 1.9781 6.5919
PFSK-1 GDSC1 4.8115 7.138 2.4961 2.983
DBTRG-05MG GDSC1 4.9036 7.4029 2.4304 3.2437
GI-1 GDSC1 5.0627 7.3056 2.5569 2.1963
Onda 10 GDSC1 5.0778 7.6433 2.4203 3.0045
SW1783 GDSC1 5.0793 8.0917 2.2235 4.2767
Onda 11 GDSC1 5.0968 7.0287 2.688 1.4216
NMC-G1 GDSC1 5.1162 6.6446 2.8468 0.6662
KINGS-1 GDSC1 5.2588 8.8855 1.9701 5.6111
GB-1 GDSC1 5.2826 6.6249 2.9198 0.3194
LN-229 GDSC1 5.3751 7.1431 2.7663 0.7865
LN-405 GDSC1 5.4136 7.0451 2.8186 0.5636
U-87MG ATCC GDSC1 5.4427 7.6971 2.5799 1.5765
DK-MG GDSC1 5.4615 6.6577 2.9731 0.1409
MOG-G-UVW GDSC1 5.4844 7.6357 2.6233 1.3183
SF539 GDSC1 5.5022 7.6036 2.6438 1.2046
KNS-42 GDSC1 5.5512 6.8151 2.9511 0.1566
CAS-1 GDSC1 5.5684 7.2212 2.8151 0.484
T98G GDSC1 5.5996 12.0212 0.7205 12.8464
D-502MG GDSC1 5.6336 7.8816 2.5932 1.3105
YH-13 GDSC1 5.6832 7.2045 2.8643 0.2952
M059J GDSC1 5.8144 7.6521 2.7546 0.539
KNS-81-FD GDSC1 5.8342 8.1587 2.5732 1.2127
SF268 GDSC1 6.0441 7.8562 2.7688 0.3886
SW1088 GDSC1 6.0752 7.8835 2.7707 0.3711
SF126 GDSC1 6.1445 7.6951 2.8602 0.1681
SK-MG-1 GDSC1 6.1628 7.9184 2.7905 0.2934
D-392MG GDSC1 6.3321 8.3953 2.6857 0.4832
ONS-76 GDSC1 6.3618 7.9923 2.8353 0.1602
SNB-75 GDSC1 6.4522 8.348 2.7462 0.2941
KALS-1 GDSC1 6.6392 8.6818 2.6983 0.3351
KS-1 [Human Krukenberg tumour] GDSC1 6.9187 9.1511 2.6368 0.3753
⏷ Show the Full List of 54 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 3 Cell Line(s) in Digestive System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TGBC1TKB GDSC1 4.6728 7.4103 2.2929 4.6367
TGBC24TKB GDSC1 5.3613 7.4725 2.6323 1.4044
ETK-1 GDSC1 5.9927 8.6672 2.4446 1.6487
Cancer Drug Sensitivity Data Curated from 8 Cell Line(s) in Endometrium Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KLE GDSC1 4.2144 6.3977 2.4773 4.368
MFE-319 GDSC1 4.347 6.6761 2.4314 4.3861
EN GDSC1 4.8742 6.5193 2.7894 1.1576
RL95-2 GDSC1 4.9765 6.5515 2.8229 0.8888
MFE-296 GDSC1 5.0292 7.905 2.2783 4.0099
ESS-1 GDSC1 5.043 10.1321 1.2499 10.9652
AN3-CA GDSC1 5.3261 7.6608 2.5395 1.9313
MFE-280 GDSC1 5.9207 8.0899 2.6358 0.8859
⏷ Show the Full List of 8 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 32 Cell Line(s) in Kidney Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
VMRC-RCZ GDSC1 3.6772 4.9683 2.7994 3.3555
769-P GDSC1 3.7155 5.6934 2.4718 5.7748
SN12C GDSC1 4.4005 7.0526 2.289 5.2923
786-O GDSC1 4.4136 6.1106 2.7284 2.1874
RCC10RGB GDSC1 4.7703 6.6589 2.6812 1.8955
A-704 GDSC1 4.8237 7.3194 2.4227 3.4425
A-498 GDSC1 4.9255 6.5814 2.7882 1.1063
ACHN GDSC1 4.9323 8.2601 2.06 5.6928
BFTC-909 GDSC1 5.0657 7.3739 2.5296 2.3538
KTCTL-140 GDSC1 5.143 7.0053 2.7187 1.2142
SW13 GDSC1 5.1734 7.1238 2.6853 1.3469
VMRC-RCW GDSC1 5.305 7.099 2.7535 0.8974
BB65-RCC GDSC1 5.3291 7.3573 2.6634 1.2864
OS-RC-2 GDSC1 5.3469 7.5181 2.6074 1.546
NCC021 GDSC1 5.3598 7.5097 2.6168 1.4838
KTCTL-26A GDSC1 5.3639 7.335 2.6877 1.1363
KMRC-1 GDSC1 5.3725 12.3698 0.399 15.2746
LB1047-RCC GDSC1 5.3774 8.0711 2.3939 2.6907
UO-31 GDSC1 5.5213 8.551 2.264 3.246
KMRC-20 GDSC1 5.6408 8.0644 2.5242 1.6354
RXF 393L GDSC1 5.6717 8.1043 2.5224 1.6102
LB996-RCC GDSC1 5.6926 7.6743 2.6978 0.8151
KTCTL-13 GDSC1 5.7177 7.8501 2.6418 1.0198
KTCTL-21 GDSC1 5.753 8.0081 2.5962 1.1847
LB2241-RCC GDSC1 5.8337 7.8142 2.703 0.699
KTCTL-195 GDSC1 5.8647 7.5121 2.8234 0.3245
KTCTL-1M GDSC1 5.9121 14.6403 -0.324 17.6039
Caki-1 GDSC1 6.0658 7.9379 2.748 0.4338
CAL-54 GDSC1 6.0848 7.7147 2.8327 0.2313
HA7-RCC GDSC1 6.1405 8.1463 2.702 0.5278
SW156 GDSC1 6.1628 8.1895 2.6951 0.5371
TK-10 GDSC1 6.1941 7.9916 2.7764 0.3137
⏷ Show the Full List of 32 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 44 Cell Line(s) in Large Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SW1463 GDSC1 -0.5615 259.3162 -127.903 49.9826
HCT 116 GDSC1 3.3692 6.0222 2.034 10.3602
HT115 GDSC1 3.9612 6.2115 2.3959 5.6396
RCM-1 [Human ESC] GDSC1 4.0847 5.3474 2.8821 1.7815
SNU-175 GDSC1 4.243 6.8932 2.2609 5.8951
SNU-1040 GDSC1 4.2479 6.3825 2.5059 4.0791
LS513 GDSC1 4.2773 6.0932 2.6578 2.9305
CW-2 GDSC1 4.3354 7.0784 2.2343 5.8546
SNU-C1 GDSC1 4.3876 6.8594 2.3714 4.7247
LS411N GDSC1 4.4784 5.9302 2.8403 1.3879
GP5d GDSC1 4.4914 6.536 2.583 3.0084
SW948 GDSC1 4.5706 6.2655 2.7455 1.8148
KM12 GDSC1 4.5763 6.5554 2.6225 2.584
SW1417 GDSC1 4.6264 6.4116 2.7121 1.9309
COLO205 GDSC1 4.6416 6.6317 2.6249 2.4521
SNU-C5 GDSC1 4.677 7.1246 2.4257 3.7087
COLO 320HSR GDSC1 4.685 9.0927 1.5056 10.1877
SW620 GDSC1 4.687 7.4425 2.2867 4.6492
CCK-81 GDSC1 4.751 7.4056 2.3419 4.1314
HCT 15 GDSC1 4.7592 7.7305 2.1982 5.111
SW626 GDSC1 4.8008 7.0072 2.5475 2.6714
HT-55 GDSC1 4.8296 6.4627 2.7915 1.1988
SW48 GDSC1 4.9102 7.3047 2.4771 2.9312
T84 GDSC1 4.9775 7.1408 2.5831 2.1679
HT-29 GDSC1 5.0216 6.7351 2.7708 1.0888
CaR-1 GDSC1 5.0221 7.7145 2.3588 3.4951
CL-11 GDSC1 5.1071 7.5846 2.4612 2.7033
NCI-H747 GDSC1 5.1852 12.0686 0.414 15.6942
LS180 GDSC1 5.255 7.5457 2.5524 1.9533
SNU-81 GDSC1 5.2812 6.9861 2.7865 0.7793
SNU-407 GDSC1 5.2923 7.3737 2.6401 1.4418
NCI-H716 GDSC1 5.3157 7.1116 2.7533 0.8892
LS1034 GDSC1 5.3432 6.801 2.8799 0.4049
RKO GDSC1 5.4436 7.7667 2.5523 1.7173
LoVo GDSC1 5.5029 10.8255 1.2231 9.996
MDST8 GDSC1 5.5227 6.7733 2.9553 0.1564
SW1116 GDSC1 5.6056 7.2213 2.8294 0.4216
SNU-61 GDSC1 5.6428 7.4349 2.7664 0.5998
HCC2998 GDSC1 5.7978 7.7538 2.7109 0.6943
SW837 GDSC1 5.8708 7.8676 2.6981 0.6923
COLO 678 GDSC1 5.9662 7.8138 2.7546 0.4614
C2BBe1 GDSC1 6.0627 7.8399 2.7814 0.3499
LS123 GDSC1 6.0691 7.6518 2.8486 0.206
SNU-C2B GDSC1 6.182 9.0996 2.3589 1.8624
⏷ Show the Full List of 44 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Leukemia Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MO-T GDSC1 3.9568 6.3816 2.31 6.3069
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Liver Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SNU-423 GDSC1 3.8004 5.8956 2.4349 5.8042
SK-HEP-1 GDSC1 4.4214 7.5008 2.0903 6.6936
SNU-398 GDSC1 4.539 10.8645 0.5364 16.8523
Hep 3B2.1-7 GDSC1 4.6185 8.5506 1.7207 8.8531
SNU-475 GDSC1 4.6314 6.6107 2.6285 2.4471
JHH-7 GDSC1 4.8084 10.7046 0.8106 14.4112
JHH-1 GDSC1 4.8542 9.0115 1.6583 8.6817
Huh-7 GDSC1 5.1191 7.0828 2.6766 1.4546
HuH-1 GDSC1 5.3115 7.0738 2.766 0.8393
SNU-387 GDSC1 5.3444 12.147 0.4872 14.8525
Hep-G2/C3A GDSC1 5.4868 6.7757 2.9419 0.1914
JHH-2 GDSC1 6.0846 7.9295 2.758 0.3994
JHH-4 GDSC1 6.171 7.9217 2.7923 0.2869
JHH-6 GDSC1 6.3785 13.9435 0.3195 13.243
HLE GDSC1 6.4122 8.269 2.7591 0.2802
SNU-449 GDSC1 6.6136 8.3661 2.7966 0.1665
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 171 Cell Line(s) in Lung Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
NCI-H847 GDSC1 3.4212 4.524 2.8255 3.9548
COR-L303 GDSC1 3.4552 5.8456 2.193 8.8131
DMS 273 GDSC1 3.4655 4.8091 2.7187 4.6449
NCI-H1694 GDSC1 3.5844 5.0782 2.6772 4.5831
Lu-139 GDSC1 3.8482 7.0945 1.8795 9.9221
BEN GDSC1 3.8854 6.4845 2.2081 7.2975
LCLC-97TM1 GDSC1 3.9049 6.8025 2.0661 8.3257
IST-SL1 GDSC1 3.9109 5.5732 2.6689 3.7095
NCI-H647 GDSC1 3.938 8.4782 1.2624 14.1193
HCC78 GDSC1 4.0003 6.169 2.4436 5.1695
NCI-H226 GDSC1 4.0379 6.8815 2.1243 7.4873
CAL-12T GDSC1 4.0961 7.9483 1.6437 10.9013
NCI-H1836 GDSC1 4.1178 5.8686 2.6637 3.2404
NCI-H23 GDSC1 4.1197 7.2106 2.0222 8.0212
NCI-H1755 GDSC1 4.1252 6.0874 2.5659 3.9348
NCI-H841 GDSC1 4.1345 6.573 2.341 5.5823
COR-L105 GDSC1 4.1701 6.4801 2.4093 4.9798
LK-2 GDSC1 4.1712 7.8666 1.7388 9.9784
COR-L23 GDSC1 4.1799 8.0772 1.642 10.6592
EMC-BAC-1 GDSC1 4.2069 6.6051 2.3742 5.1465
NCI-H526 GDSC1 4.2127 7.154 2.115 7.0649
NCI-H2081 GDSC1 4.2874 6.9138 2.2807 5.634
NCI-H2731 GDSC1 4.2892 7.7978 1.8567 8.7697
COLO 668 GDSC1 4.3824 6.7551 2.4168 4.4089
SBC-5 GDSC1 4.3983 5.8647 2.8269 1.5891
SBC-3 GDSC1 4.4155 6.1666 2.7047 2.3389
NCI-H82 GDSC1 4.4257 5.9583 2.8012 1.7038
NCI-H345 GDSC1 4.4595 5.3966 3.0448 0.3868
CPC-N GDSC1 4.4802 7.164 2.2876 5.1113
NCI-H1944 GDSC1 4.4893 9.9011 0.9733 14.3197
Ms-1 GDSC1 4.4966 8.1178 1.8456 8.2809
NCI-H2444 GDSC1 4.5177 5.9633 2.8461 1.299
NCI-H720 GDSC1 4.5263 6.7177 2.5214 3.3589
NCI-H2171 GDSC1 4.5741 6.2525 2.7528 1.7649
NCI-H1581 GDSC1 4.6152 7.9389 2.0099 6.7881
NCI-H661 GDSC1 4.6196 8.2503 1.865 7.8189
NCI-H2373 GDSC1 4.6731 7.7788 2.1223 5.8432
RERF-LC-MS GDSC1 4.6995 9.661 1.241 11.9525
NCI-H1876 GDSC1 4.7079 6.6532 2.6512 2.1751
IA-LM GDSC1 4.708 8.6581 1.7295 8.5565
NCI-H1048 GDSC1 4.7098 7.6668 2.1973 5.227
COR-L321 GDSC1 4.7259 6.7663 2.6119 2.3908
NCI-H810 GDSC1 4.7359 6.3729 2.7835 1.3573
Lu-65 GDSC1 4.7489 6.6031 2.6939 1.8521
NCI-H522 GDSC1 4.76 8.2213 1.9704 6.7177
NCI-H838 GDSC1 4.7729 7.5655 2.2821 4.4975
COR-L311 GDSC1 4.786 7.0627 2.5151 2.9055
NCI-H2087 GDSC1 4.8237 6.8295 2.6362 2.0835
NCI-H2196 GDSC1 4.8609 6.4788 2.7995 1.1212
HCC33 GDSC1 4.8783 6.6087 2.7552 1.3309
Calu-6 GDSC1 4.8825 7.0401 2.5769 2.3523
EBC-1 GDSC1 4.898 8.1203 2.1034 5.467
NCI-H2369 GDSC1 4.899 6.6842 2.7343 1.417
NCI-H1436 GDSC1 4.8993 6.6001 2.7686 1.2355
NCI-H2141 GDSC1 4.9009 6.4077 2.8457 0.8568
NCI-H1573 GDSC1 4.9142 7.6172 2.3413 3.8113
NCI-H1781 GDSC1 4.9216 6.2332 2.9211 0.523
A-427 GDSC1 4.9595 7.1942 2.5512 2.3877
NCI-H1838 GDSC1 4.96 7.0605 2.6082 2.046
NCI-H2030 GDSC1 4.9833 7.1763 2.5711 2.2307
DMS 53 GDSC1 4.9956 6.9756 2.6613 1.6923
NCI-H1563 GDSC1 4.9981 6.8842 2.7 1.4778
NCI-H2029 GDSC1 5.0019 6.8713 2.7071 1.4352
UMC-11 GDSC1 5.0023 7.1795 2.5794 2.1529
NCI-H187 GDSC1 5.003 6.2451 2.9492 0.3736
NCI-H196 GDSC1 5.0109 6.3137 2.9272 0.4414
NCI-H1155 GDSC1 5.025 6.7419 2.7696 1.091
NCI-H1568 GDSC1 5.0421 9.8149 1.4007 9.9664
NCI-H1975 GDSC1 5.047 8.957 1.8082 7.1758
NCI-H1304 GDSC1 5.0867 6.4711 2.8995 0.4898
NCI-H1688 GDSC1 5.116 7.1302 2.6559 1.5678
Lu-165 GDSC1 5.1262 6.6711 2.841 0.6819
NCI-H1355 GDSC1 5.1536 7.2395 2.6292 1.6639
DMS 114 GDSC1 5.1839 7.9521 2.3433 3.3098
NCI-H2023 GDSC1 5.1972 6.8441 2.8051 0.7709
NCI-H1435 GDSC1 5.1977 7.0383 2.7302 1.1021
NCI-H69 GDSC1 5.218 7.34 2.6189 1.6389
DMS 79 GDSC1 5.2441 6.7928 2.8438 0.5851
NCI-H209 GDSC1 5.255 10.0771 1.4157 9.3383
LC-1/sq GDSC1 5.2932 7.8526 2.4433 2.5247
NCI-H1437 GDSC1 5.2987 11.2393 0.8924 12.5761
NCI-H596 GDSC1 5.3121 6.7039 2.9028 0.353
NCI-H2172 GDSC1 5.3393 7.0305 2.7939 0.705
NCI-H524 GDSC1 5.3552 7.3789 2.6666 1.2438
SW1573 GDSC1 5.3567 7.8602 2.472 2.2676
NCI-H2122 GDSC1 5.3688 6.8118 2.8858 0.3744
NCI-H460 GDSC1 5.3727 6.47 3.0056 0.1091
NCI-H2085 GDSC1 5.3733 7.7127 2.541 1.8633
NCI-H1793 GDSC1 5.3772 7.4631 2.6433 1.3336
Lu-99A GDSC1 5.3778 7.9457 2.4468 2.3818
NCI-H2009 GDSC1 5.3926 7.6822 2.5625 1.7251
NCI-H520 GDSC1 5.4041 7.587 2.6062 1.4873
COR-L88 GDSC1 5.4137 8.1385 2.3839 2.6956
HARA [Human squamous cell lung carcinoma] GDSC1 5.4304 7.2526 2.748 0.8168
NCI-H2135 GDSC1 5.4373 6.8402 2.9014 0.3008
NCI-H2291 GDSC1 5.4519 7.5099 2.6583 1.1868
LOU-NH91 GDSC1 5.4541 7.5849 2.6298 1.3184
NCI-H2227 GDSC1 5.4552 7.0192 2.8444 0.4544
NCI-H211 GDSC1 5.4682 7.6625 2.6054 1.4217
NCI-H2170 GDSC1 5.4714 7.5049 2.6687 1.1204
NCI-H290 GDSC1 5.4816 7.0954 2.827 0.4947
IST-SL2 GDSC1 5.4818 18.0041 -2.2806 26.1896
COR-L95 GDSC1 5.4842 7.0219 2.8545 0.4085
SBC-1 GDSC1 5.5058 7.095 2.8365 0.4514
NCI-H441 GDSC1 5.5073 8.4723 2.2903 3.1096
NCI-H1734 GDSC1 5.5144 7.6016 2.6499 1.165
ChaGo-K-1 GDSC1 5.5166 7.973 2.5031 1.888
NCI-H1915 GDSC1 5.5269 7.2779 2.778 0.633
LCLC-103H GDSC1 5.5318 6.9434 2.9001 0.2671
NCI-H3255 GDSC1 5.541 7.5216 2.6923 0.9562
Lu-135 GDSC1 5.5421 7.3976 2.7397 0.7646
NCI-H748 GDSC1 5.5431 7.5725 2.6736 1.0338
NCI-H1770 GDSC1 5.5439 7.0644 2.862 0.3588
NCI-H1623 GDSC1 5.5484 7.543 2.6872 0.9711
NCI-H2818 GDSC1 5.5683 7.2214 2.8151 0.4842
Lu-134-A GDSC1 5.592 7.5035 2.7204 0.8019
LC-2/ad GDSC1 5.6054 7.6662 2.6643 1.0197
NCI-H1703 GDSC1 5.6069 12.3838 0.5523 13.803
NCI-H650 GDSC1 5.6192 7.2854 2.8116 0.4677
NCI-H1666 GDSC1 5.6236 7.5756 2.7064 0.8329
NCI-H1869 GDSC1 5.641 8.4252 2.3775 2.4112
NCI-H1993 GDSC1 5.6431 7.5283 2.7321 0.7213
HOP-62 GDSC1 5.6445 8.2298 2.4593 1.9637
NCI-H446 GDSC1 5.6516 7.3222 2.8108 0.4532
NCI-H3122 GDSC1 5.6538 7.8341 2.6205 1.1673
HCC44 GDSC1 5.67 7.7458 2.6613 0.9782
Calu-3 GDSC1 5.6741 7.1969 2.8636 0.3004
NCI-H727 GDSC1 5.6861 7.5346 2.747 0.6394
NCI-H1792 GDSC1 5.6897 11.7011 0.9313 11.3659
ABC-1 GDSC1 5.7085 7.8163 2.6508 0.9901
NCI-H510A GDSC1 5.7117 7.3304 2.8306 0.3688
SK-LU-1 GDSC1 5.7146 7.5713 2.7449 0.629
RERF-LC-KJ GDSC1 5.72 7.3352 2.832 0.3615
HCC15 GDSC1 5.7224 10.0208 1.7282 6.2621
LXF 289 GDSC1 5.7567 7.7121 2.7098 0.7252
EMC-BAC-2 GDSC1 5.7574 7.7554 2.694 0.7829
NCI-H2803 GDSC1 5.7755 7.8565 2.6635 0.8861
NCI-H358 GDSC1 5.7893 7.913 2.6479 0.9372
SW1271 GDSC1 5.8017 7.4595 2.8185 0.3619
NCI-H64 GDSC1 5.8042 12.371 0.6893 12.5276
NCI-H2405 GDSC1 5.8167 8.0357 2.6129 1.0581
PaCa-3 GDSC1 5.8364 8.2037 2.5568 1.2833
NCI-H1651 GDSC1 5.8486 7.9667 2.6523 0.8751
NCI-H2342 GDSC1 5.8506 7.9154 2.6723 0.7983
EPLC-272H GDSC1 5.8532 7.73 2.7414 0.559
RERF-LC-Sq1 GDSC1 5.8538 9.4176 2.0667 3.9072
NCI-H2228 GDSC1 5.8815 11.9128 0.9547 10.7747
NCI-H2461 GDSC1 5.8863 7.6193 2.7937 0.3908
NCI-H1299 GDSC1 5.8895 7.7644 2.743 0.5343
NCI-H292 GDSC1 5.8972 7.4448 2.8584 0.2356
NCI-H2804 GDSC1 5.8996 7.9658 2.6734 0.761
SK-MES-1 GDSC1 5.9055 7.7998 2.7364 0.546
NCI-H2795 GDSC1 5.9108 7.991 2.6686 0.7707
NCI-H2591 GDSC1 5.9191 7.7172 2.7713 0.4368
PC-14 GDSC1 5.9463 7.7285 2.7774 0.4078
NCI-H1693 GDSC1 5.9759 8.0541 2.6714 0.7185
NCI-H1092 GDSC1 6.0171 7.6813 2.82 0.2779
HCC827 GDSC1 6.0242 7.5583 2.8646 0.1891
NCI-H2722 GDSC1 6.0268 7.5702 2.8614 0.1939
NCI-H322M GDSC1 6.0403 8.0274 2.7063 0.5666
SHP-77 GDSC1 6.1355 13.2524 0.4883 12.884
NCI-H1648 GDSC1 6.2265 8.6199 2.5627 0.9425
NCI-H2869 GDSC1 6.2594 8.1945 2.7295 0.4001
EKVX GDSC1 6.2976 8.4964 2.6364 0.6446
NCI-H513 GDSC1 6.3115 8.104 2.7798 0.2688
A-549 GDSC1 6.3323 8.2225 2.7464 0.3329
NCI-H2110 GDSC1 6.3551 8.5722 2.6312 0.6295
NCI-H1650 GDSC1 6.4803 8.3263 2.7637 0.2517
NCI-H2347 GDSC1 6.5013 8.2775 2.7876 0.2044
NCI-H2595 GDSC1 6.5429 8.4172 2.7548 0.2513
HOP-92 GDSC1 6.5516 8.9275 2.5788 0.6858
⏷ Show the Full List of 171 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Lymphoma Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
CBTCi002-A GDSC1 4.2868 7.3102 2.0907 7.0449
Cancer Drug Sensitivity Data Curated from 24 Cell Line(s) in Oesophagus Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TE-15 GDSC1 3.6874 5.7263 2.4346 6.1516
TE-10 GDSC1 4.0614 5.8994 2.6133 3.7424
KYSE-450 GDSC1 4.1395 5.591 2.8044 2.2012
T.T GDSC1 4.2105 6.4632 2.4439 4.6227
TE-9 GDSC1 4.3347 6.7137 2.406 4.599
KYSE-270 GDSC1 4.5918 6.7798 2.5315 3.1601
KYSE-70 GDSC1 4.7611 6.9692 2.5425 2.7726
TE-11 GDSC1 4.771 7.3189 2.3927 3.7453
TE-6 GDSC1 4.84 6.9846 2.5783 2.4118
TE-1 GDSC1 4.9159 7.1236 2.5586 2.4113
KYSE-140 GDSC1 5.0225 7.1073 2.6199 1.8888
TE-8 GDSC1 5.1413 7.3075 2.5953 1.8659
OE19 GDSC1 5.1913 7.3575 2.599 1.7802
TE-5 GDSC1 5.2072 6.8996 2.7882 0.8336
KYSE-150 GDSC1 5.3083 7.3247 2.6669 1.2912
TE-4 GDSC1 5.3297 7.4371 2.632 1.441
OE33 GDSC1 5.4454 8.1547 2.3931 2.5951
EC-GI-10 GDSC1 5.5144 7.4934 2.6918 0.9809
COLO 680N GDSC1 5.5413 7.1515 2.8299 0.453
KYSE-180 GDSC1 5.5599 8.077 2.4813 1.9503
KYSE-510 GDSC1 5.9673 7.3663 2.9095 0.1307
KYSE-410 GDSC1 6.0563 7.95 2.7401 0.4597
OE21 GDSC1 6.061 7.8439 2.7794 0.3555
KYSE-520 GDSC1 6.1837 8.6547 2.532 1.0931
⏷ Show the Full List of 24 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 29 Cell Line(s) in Ovary Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
TOV-21G GDSC1 0.1984 4.8092 -0.5728 42.244
TOV-112D GDSC1 3.5178 4.7214 2.8031 3.81
JHOS-2 GDSC1 3.8818 6.5449 2.1758 7.5564
OAW42 GDSC1 4.1607 6.4963 2.3954 5.1077
OVCAR-4 GDSC1 4.3643 6.1205 2.6962 2.4919
OVK18 GDSC1 4.4337 6.6566 2.494 3.7438
DOV13 GDSC1 4.4708 6.5777 2.5522 3.2604
SK-OV-3 GDSC1 4.5464 6.5426 2.6114 2.7122
FU-OV-1 GDSC1 4.6063 6.7214 2.5658 2.9026
ES-2 GDSC1 4.6903 6.8718 2.5463 2.8755
OVCAR-8 GDSC1 4.7005 10.1537 1.0021 13.5153
A2780 GDSC1 4.8038 7.3891 2.3801 3.7653
OC 314 GDSC1 4.8373 7.6552 2.2796 4.381
IGROV-1 GDSC1 5.0215 7.0143 2.6579 1.6766
OV56 GDSC1 5.1881 6.2279 3.0232 0.122
OV-90 GDSC1 5.2154 7.8755 2.3932 2.9466
OAW28 GDSC1 5.2633 7.4966 2.5766 1.8096
EFO-27 GDSC1 5.2961 7.2563 2.6884 1.2004
OVISE GDSC1 5.312 6.4852 2.9792 0.169
Caov-3 GDSC1 5.5045 7.2158 2.792 0.5983
Caov-4 GDSC1 5.6174 7.4511 2.7503 0.6723
EFO-21 GDSC1 5.6564 7.3236 2.8121 0.4467
OVCAR-3 GDSC1 5.8141 7.4522 2.8257 0.3385
RMG-I GDSC1 5.8219 7.8878 2.6709 0.8237
Kuramochi GDSC1 5.9389 7.7658 2.7614 0.4551
OVCAR-5 GDSC1 5.9887 7.7807 2.7748 0.3963
OVKATE GDSC1 5.999 7.6327 2.8302 0.262
TYK-nu GDSC1 6.0377 7.6771 2.8288 0.2529
OVTOKO GDSC1 6.0634 7.9606 2.7391 0.4593
⏷ Show the Full List of 29 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 30 Cell Line(s) in Pancreas Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
KP-4 GDSC1 3.7148 12.5154 -0.9282 26.6564
HPAF-II GDSC1 3.9191 5.6519 2.6367 3.9298
SUIT-2 GDSC1 4.3144 6.8367 2.335 5.1662
PaTu 8902 GDSC1 4.3894 6.3225 2.6199 2.9607
MIA PaCa-2 GDSC1 4.3955 6.3527 2.6099 3.0175
PSN1 GDSC1 4.4509 6.9193 2.3833 4.4919
SU.86.86 GDSC1 4.7681 6.4573 2.7643 1.4209
Hs 766T GDSC1 4.8483 7.4983 2.3567 3.8357
Capan-1 GDSC1 4.9234 6.7317 2.7266 1.4278
DAN-G GDSC1 4.9316 9.8819 1.2945 10.9627
Panc 02.03 GDSC1 4.9578 8.645 1.8975 6.7642
PaTu 8988t GDSC1 4.9775 9.6679 1.4278 9.949
SW1990 GDSC1 5.035 8.68 1.9292 6.369
BxPC-3 GDSC1 5.1366 9.8265 1.4572 9.3505
CFPAC-1 GDSC1 5.2229 8.2122 2.2507 3.8316
KP-2 GDSC1 5.2248 6.2454 3.0301 0.103
QGP-1 GDSC1 5.2878 6.65 2.9128 0.3362
YAPC GDSC1 5.3029 8.479 2.1775 4.1582
HuP-T4 GDSC1 5.3493 7.1382 2.7573 0.844
PL4 GDSC1 5.3768 7.415 2.6621 1.2436
Panc 03.27 GDSC1 5.6181 7.1581 2.8565 0.3408
Panc 08.13 GDSC1 5.6877 8.3971 2.4117 2.1635
AsPC-1 GDSC1 5.8635 9.0363 2.2333 2.9162
MZ-PC-1 GDSC1 5.8845 8.7254 2.3715 2.1342
HuP-T3 GDSC1 6.0531 7.9051 2.7549 0.4211
Panc 10.05 GDSC1 6.1229 8.0368 2.7344 0.4453
Panc 04.03 GDSC1 6.1811 11.3312 1.4042 7.391
HPAC GDSC1 6.202 7.7563 2.8595 0.1569
Capan-2 GDSC1 6.2418 7.9227 2.8171 0.2175
KP-3 GDSC1 6.3564 8.3719 2.7031 0.4273
⏷ Show the Full List of 30 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 6 Cell Line(s) in Pleura Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
MSTO-211H GDSC1 4.1531 7.3835 1.9618 8.3784
MPP 89 GDSC1 4.7858 7.0498 2.5207 2.8697
NCI-H2052 GDSC1 5.0441 6.9301 2.7032 1.405
NCI-H28 GDSC1 5.4338 7.7039 2.5731 1.6218
IST-Mes1 GDSC1 6.0482 7.6596 2.8385 0.2304
NCI-H2452 GDSC1 6.1232 8.1415 2.6971 0.5511
⏷ Show the Full List of 6 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 5 Cell Line(s) in Prostate Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
LNCaP clone FGC GDSC1 4.8213 8.2689 1.987 6.4551
VCaP GDSC1 5.1807 6.6952 2.8544 0.5898
22Rv1 GDSC1 5.2329 7.5115 2.5557 1.9644
PC-3 GDSC1 5.259 8.1254 2.3084 3.4016
DU145 GDSC1 5.7482 7.8451 2.6565 0.935
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Salivary Gland Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A-253 GDSC1 4.7322 7.5532 2.2633 4.7148
Cancer Drug Sensitivity Data Curated from 56 Cell Line(s) in Skin Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
A2058 GDSC1 3.9872 6.1131 2.4616 5.0691
SK-MEL-3 GDSC1 4.1619 5.5958 2.8152 2.083
SK-MEL-5 GDSC1 4.186 6.7971 2.2685 5.9885
UACC-62 GDSC1 4.2088 5.872 2.7178 2.6565
CP50-MEL-B GDSC1 4.2522 6.0903 2.644 3.0808
RPMI-7951 GDSC1 4.3036 7.7211 1.904 8.3813
LB2518-MEL GDSC1 4.3339 6.6013 2.458 4.2247
SK-MEL-2 GDSC1 4.3522 6.2855 2.6148 3.0728
CHL-1 GDSC1 4.3969 7.9107 1.8771 8.321
VMRC-MELG GDSC1 4.4721 5.9595 2.8248 1.4884
SK-MEL-28 GDSC1 4.5104 6.7047 2.5179 3.4151
CP66-MEL GDSC1 4.5517 6.7893 2.5039 3.4273
M14 GDSC1 4.6135 7.2648 2.3237 4.5501
HMV-II GDSC1 4.6281 7.4757 2.2352 5.1435
WT2-iPS GDSC1 4.6414 6.1491 2.8297 1.2259
GAK GDSC1 4.6668 8.4154 1.8178 8.0357
IPC-298 GDSC1 4.6965 8.4351 1.828 7.8866
MZ-MEL-7 GDSC1 4.7558 7.0044 2.5241 2.9014
SK-MEL-1 GDSC1 4.7647 6.0906 2.9093 0.6977
COLO 783 GDSC1 4.7848 6.3092 2.8323 1.0411
G-mel GDSC1 4.8396 10.3024 1.0282 12.9547
451Lu GDSC1 4.9408 7.414 2.446 3.0769
WM115 GDSC1 4.9444 8.5108 1.9515 6.4191
LOX-IMVI GDSC1 4.9496 7.0873 2.5915 2.1598
A101D GDSC1 4.9516 6.4336 2.8577 0.7567
UACC-257 GDSC1 4.9839 6.528 2.8352 0.8264
WM1552C GDSC1 5.0084 6.6938 2.7812 1.0526
LB373-MEL-D GDSC1 5.0097 6.3294 2.921 0.4639
COLO 679 GDSC1 5.0558 7.1271 2.6281 1.7974
Hs 940.T GDSC1 5.0564 7.063 2.6548 1.6488
A-431 GDSC1 5.0885 7.24 2.5973 1.9259
COLO 800 GDSC1 5.0993 9.3159 1.6735 7.9772
DJM-1 GDSC1 5.1131 8.3906 2.1086 4.9788
MMAc-SF GDSC1 5.1206 6.5159 2.8965 0.4786
SK-MEL-30 GDSC1 5.1702 6.2639 3.0047 0.1605
COLO 792 GDSC1 5.2 7.4059 2.5833 1.8549
IGR-37 GDSC1 5.2321 6.5028 2.9441 0.2767
MeWo GDSC1 5.2348 7.2059 2.6807 1.3025
SK-MEL-24 GDSC1 5.2492 6.618 2.9096 0.3642
Hs 938.T GDSC1 5.2856 6.8504 2.8392 0.5738
Mel JuSo GDSC1 5.3532 7.5605 2.5933 1.6115
A-388 GDSC1 5.3716 8.1526 2.3563 2.9238
IGR-1 GDSC1 5.419 7.0637 2.8139 0.5764
RVH-421 GDSC1 5.4796 6.7998 2.931 0.2161
Mel Ho GDSC1 5.6339 6.7084 3.0149 0.0577
IST-MEL1 GDSC1 5.6709 7.4958 2.7552 0.6206
WM793 GDSC1 5.7185 7.4969 2.7736 0.532
G-361 GDSC1 5.7278 6.997 2.951 0.118
A-375 GDSC1 5.7725 7.2791 2.8708 0.2491
WM278 GDSC1 5.8715 7.7619 2.737 0.5629
MZ-MEL-2 GDSC1 5.9253 7.7063 2.7775 0.417
SH-4 GDSC1 6.0292 8.0232 2.7035 0.5812
HT-144 GDSC1 6.2567 7.9932 2.7984 0.2484
COLO 829 GDSC1 6.3266 7.8655 2.8657 0.1251
WM35 GDSC1 6.3766 8.7713 2.5671 0.8262
EquiPSC Line K2 GDSC1 5.7973 8.1075 2.577 1.2293
⏷ Show the Full List of 56 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 1 Cell Line(s) in Small Intestine Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HuTu 80 GDSC1 4.1147 6.7837 2.2259 6.5012
Cancer Drug Sensitivity Data Curated from 21 Cell Line(s) in Soft Tissue Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SK-LMS-1 GDSC1 3.616 4.9442 2.7669 3.7868
SW684 GDSC1 3.949 6.1159 2.4336 5.3864
Hs 633.T GDSC1 4.3456 6.0351 2.7237 2.3436
EW-8 GDSC1 4.582 7.3268 2.2757 4.9609
MES-SA GDSC1 4.5943 7.611 2.1509 5.8252
VA-ES-BJ GDSC1 4.6143 7.4656 2.2313 5.2029
Rh30 GDSC1 4.6305 6.9374 2.483 3.412
G-401 GDSC1 4.7348 6.9559 2.5339 2.8756
Rh41 GDSC1 4.7564 7.3224 2.3827 3.8423
SW872 GDSC1 4.8552 7.58 2.3241 4.0421
KYM-1 GDSC1 4.891 6.9149 2.6345 1.9924
RKN GDSC1 4.9372 6.0719 2.9862 0.2954
TE 441.T GDSC1 4.9765 6.1811 2.9621 0.3477
GCT GDSC1 5.0264 7.6663 2.3823 3.3352
SW982 GDSC1 5.0288 6.5878 2.8316 0.802
HT-1080 GDSC1 5.0733 7.1832 2.6134 1.8558
G-402 GDSC1 5.1163 8.1441 2.2212 4.221
SK-UT-1 GDSC1 5.2608 8.3856 2.1953 4.1201
MFH-ino GDSC1 5.5374 7.7018 2.621 1.2761
RD GDSC1 5.9168 8.1825 2.5992 1.0329
A-204 GDSC1 6.1251 8.7273 2.4794 1.3623
⏷ Show the Full List of 21 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 26 Cell Line(s) in Stomach Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
Hs 746.T GDSC1 -2.9354 8.7993 -5.4979 60.1169
GCIY GDSC1 2.7733 3.5716 2.6505 8.1181
HGC-27 GDSC1 3.3332 5.1263 2.4519 7.2143
IM95 GDSC1 3.6578 5.8148 2.3683 6.7622
SNU-1 GDSC1 4.0405 5.9894 2.5569 4.2122
RERF-GC-1B GDSC1 4.2299 6.8813 2.2578 5.9524
SNU-16 GDSC1 4.2575 6.806 2.3122 5.4774
MKN7 GDSC1 4.2582 7.6442 1.9094 8.4684
HSC-39 GDSC1 4.4439 8.7536 1.5014 10.8895
OCUM-1 GDSC1 4.4569 7.3687 2.1763 5.9744
MKN45 GDSC1 4.4937 5.6429 2.9647 0.7035
AGS GDSC1 4.5789 6.9417 2.4508 3.7371
23132/87 GDSC1 4.7103 7.2516 2.3877 3.9008
ECC10 GDSC1 4.719 6.5533 2.6997 1.8627
SNU-5 GDSC1 4.7579 6.5047 2.7397 1.5727
MKN1 GDSC1 4.8268 7.5353 2.3276 4.0747
SCH GDSC1 4.9932 6.766 2.7455 1.2456
Fu97 GDSC1 5.0057 6.629 2.8055 0.9405
TMK-1 GDSC1 5.0696 7.0288 2.6751 1.5222
NUGC-3 GDSC1 5.087 7.8715 2.3256 3.5928
RF-48 GDSC1 5.1733 7.4758 2.5411 2.1289
NUGC-4 GDSC1 5.4132 7.89 2.4874 2.1046
TGBC11TKB GDSC1 5.5149 7.2353 2.7889 0.6024
MKN28 GDSC1 5.5497 9.772 1.7395 6.5379
NCI-N87 GDSC1 6.371 8.1404 2.7885 0.2355
SNG-M GDSC1 3.6557 4.9557 2.7902 3.4883
⏷ Show the Full List of 26 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Thyroid Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
HTC-C3 GDSC1 3.0185 3.9904 2.7271 6.3363
IHH-4 GDSC1 4.2649 7.2259 2.1162 6.9138
BHT-101 GDSC1 4.5479 7.7549 2.053 6.6439
CAL-62 GDSC1 4.9564 6.6947 2.7571 1.2286
B-CPAP GDSC1 4.9737 9.3017 1.5992 8.791
FTC-133 GDSC1 4.9856 10.2661 1.1468 11.791
WRO GDSC1 5.3643 7.4826 2.6297 1.4141
K5 GDSC1 5.5352 7.2501 2.7916 0.5804
ML-1 [Human leukemia] GDSC1 5.661 7.286 2.8273 0.4007
TT2609-C02 GDSC1 5.6741 7.4686 2.7665 0.5807
ASH-3 GDSC1 5.7361 7.1943 2.887 0.2267
8305C GDSC1 5.7441 7.1354 2.91 0.1802
KMH-2 GDSC1 5.7468 7.4783 2.7912 0.4631
CGTH-W-1 GDSC1 5.7942 7.416 2.8311 0.3332
TT GDSC1 5.9145 7.4824 2.8517 0.244
8505C GDSC1 5.9426 7.6267 2.8118 0.3226
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 39 Cell Line(s) in Upper Aerodigestive Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
SCC-9 GDSC1 3.2923 4.9119 2.5245 6.7938
SCC-25 GDSC1 3.8065 5.5403 2.6128 4.418
SAS GDSC1 4.1536 7.0072 2.1449 7.0033
CAL-27 GDSC1 4.2653 6.3775 2.5192 3.9419
PCI-15A GDSC1 4.4681 6.7281 2.482 3.7539
BB30-HNC GDSC1 4.5187 6.4757 2.6255 2.6706
HSC-3 GDSC1 4.5549 6.2131 2.7597 1.7531
Ca9-22 GDSC1 4.6423 6.6797 2.6043 2.5841
BICR 10 GDSC1 4.6974 7.7527 2.1498 5.5916
PCI-30 GDSC1 4.7785 7.7281 2.2111 4.9789
BICR 78 GDSC1 4.831 6.8696 2.6229 2.1528
PCI-38 GDSC1 4.8738 7.1674 2.5173 2.7384
HSC-2 GDSC1 4.9238 7.153 2.5501 2.4508
CAL-33 GDSC1 4.9467 7.0139 2.621 1.9901
PE/CA-PJ15 GDSC1 5.018 8.4931 2.005 5.8847
HO-1-u-1 GDSC1 5.0847 7.3952 2.5303 2.3211
LB771-HNC GDSC1 5.1165 7.3205 2.5777 1.999
Detroit 562 GDSC1 5.139 7.3046 2.5954 1.8686
KON GDSC1 5.1441 7.3872 2.5636 2.0413
PCI-06A GDSC1 5.1485 8.0363 2.287 3.7312
JHU-011 GDSC1 5.1686 9.3353 1.7082 7.5789
BICR 22 GDSC1 5.2083 6.6944 2.8658 0.5299
FaDu GDSC1 5.2108 6.7188 2.8578 0.5567
OSC-20 GDSC1 5.2591 7.355 2.6322 1.5201
HSC-4 GDSC1 5.2824 8.9744 1.9437 5.7391
SCC-4 GDSC1 5.3221 7.3503 2.663 1.2958
SCC-15 GDSC1 5.4003 7.4893 2.6433 1.3093
SKN-3 GDSC1 5.4777 9.3277 1.8983 5.6442
NCI-H3118 GDSC1 5.544 8.3131 2.3762 2.5521
BB49-HNC GDSC1 5.5981 8.3232 2.3987 2.3505
HO-1-N-1 GDSC1 5.6523 7.9537 2.5732 1.3854
BICR 31 GDSC1 5.7522 9.7407 1.8703 5.2989
OSC-19 GDSC1 6.0372 7.7641 2.7985 0.319
DOK GDSC1 6.0793 8.2276 2.6487 0.7318
BHY GDSC1 6.2608 7.8263 2.8563 0.1498
PCI-04B GDSC1 6.3333 8.3805 2.6914 0.4673
JHU-022 GDSC1 6.4651 8.6037 2.6617 0.4887
KOSC-2 GDSC1 6.8073 8.6721 2.7607 0.1802
SAT [Human HNSCC] GDSC1 7.1239 9.4984 2.5907 0.407
⏷ Show the Full List of 39 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 16 Cell Line(s) in Urinary Tract Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
UM-UC-3 GDSC1 3.9159 5.6531 2.634 3.9586
KU-19-19 GDSC1 4.0913 6.5773 2.3094 5.9357
BFTC-905 GDSC1 4.0999 7.0013 2.11 7.417
SW1710 GDSC1 4.1046 6.0183 2.5852 3.8436
639V GDSC1 4.3369 6.3692 2.5673 3.4376
RT-112 GDSC1 4.5533 7.0738 2.3749 4.3217
CAL-29 GDSC1 4.9897 6.3715 2.8972 0.5645
TCCSUP GDSC1 5.1263 8.8895 1.8886 6.4448
647V GDSC1 5.1377 7.9399 2.3234 3.5162
SW780 GDSC1 5.1651 7.6643 2.4574 2.635
HT-1197 GDSC1 5.2923 6.8682 2.8353 0.5834
HT-1376 GDSC1 5.8112 7.5399 2.7936 0.4247
J82 GDSC1 5.9607 7.7506 2.775 0.408
T24 GDSC1 6.3091 8.3461 2.6946 0.4696
RT-4 GDSC1 6.4222 8.191 2.7893 0.2207
5637 GDSC1 6.5624 8.39 2.7709 0.2179
⏷ Show the Full List of 16 Cancer Drug Sensitivity Data of This Drug
Cancer Drug Sensitivity Data Curated from 37 Cell Line(s) in Urogenital System Tissue
Cell Line Original Dataset IC50 IC90 EC50 AUC
PA-1 GDSC1 3.1877 4.2897 2.7425 5.4863
SW954 GDSC1 3.4327 4.8757 2.6592 5.2258
ME-180 GDSC1 3.4568 4.8904 2.6712 5.0485
C-33 A GDSC1 4.3272 6.7427 2.3876 4.7507
OVMIU GDSC1 4.4687 6.78 2.4586 3.9172
HeLa GDSC1 4.5016 5.6306 2.9731 0.6563
JEG-3 GDSC1 4.5316 7.1978 2.3042 4.8727
LB831-BLC GDSC1 4.6679 7.3797 2.304 4.5698
Ca Ski GDSC1 4.6901 7.3296 2.3403 4.2694
PEO1 GDSC1 4.7038 7.7156 2.171 5.4267
NCC-IT GDSC1 4.7091 6.468 2.7306 1.6943
SiHa GDSC1 4.8272 6.1208 2.9244 0.5813
NEC8 GDSC1 4.8715 6.591 2.7592 1.3179
NT2-D1 GDSC1 4.9748 7.0928 2.602 2.0603
HEY GDSC1 4.986 6.9998 2.6466 1.7877
HEC-1 GDSC1 5.0481 6.7331 2.7835 1.0013
OVCA420 GDSC1 5.0497 6.946 2.6993 1.4184
SKN GDSC1 5.0999 7.5226 2.4839 2.5759
JHOS-3 GDSC1 5.2254 9.7291 1.5602 8.446
JAR GDSC1 5.3033 11.4379 0.8003 13.1251
MS751 GDSC1 5.3071 7.1741 2.7254 1.0187
C-4-I GDSC1 5.3223 8.215 2.3035 3.3257
OV17R GDSC1 5.3563 7.4865 2.6244 1.4493
SiSo GDSC1 5.3841 7.7286 2.5396 1.8571
SW756 GDSC1 5.4097 10.5854 1.2761 9.8781
SKG-IIIa GDSC1 5.4159 7.0764 2.808 0.5994
HT-3 GDSC1 5.4577 7.3308 2.7298 0.8691
DoTc2 4510 GDSC1 5.475 7.2033 2.7848 0.6435
DSH1 GDSC1 5.4799 7.7368 2.5812 1.5285
UWB1.289 GDSC1 5.6009 8.1155 2.4851 1.881
CAL-39 GDSC1 5.6539 7.6608 2.6869 0.8871
SW962 GDSC1 5.68 7.3537 2.8103 0.4402
KGN GDSC1 5.9073 7.7338 2.7609 0.4719
BPH-1 GDSC1 6.0645 8.3388 2.6015 0.9118
OMC-1 [Human cervical carcinoma] GDSC1 6.0801 7.8056 2.7997 0.3012
ACC-OV7 GDSC1 6.1297 8.2058 2.6764 0.6111
OVCA433 GDSC1 6.349 8.2663 2.7373 0.3477
⏷ Show the Full List of 37 Cancer Drug Sensitivity Data of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2755).
2 The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003 Nov;44(11):2039-48.
3 Isosilybin regulates lipogenesis and fatty acid oxidation via the AMPK/SREBP-1c/PPAR pathway. Chem Biol Interact. 2022 Dec 1;368:110250. doi: 10.1016/j.cbi.2022.110250. Epub 2022 Nov 5.
4 Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis. Toxicol Sci. 2017 Sep 1;159(1):159-169. doi: 10.1093/toxsci/kfx121.
5 Regulation of alpha-synuclein expression by liver X receptor ligands in vitro. Neuroreport. 2008 Nov 19;19(17):1685-9. doi: 10.1097/WNR.0b013e32831578b2.
6 Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells. Biochemistry. 2009 Dec 22;48(50):11950-60. doi: 10.1021/bi9015742.
7 Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists. Mol Hum Reprod. 2007 Jun;13(6):373-9.
8 The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver. J Lipid Res. 2005 Oct;46(10):2151-67. doi: 10.1194/jlr.M500080-JLR200. Epub 2005 Jul 16.
9 Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies. Arch Toxicol. 2018 Sep;92(9):2829-2844. doi: 10.1007/s00204-018-2263-3. Epub 2018 Jul 13.
10 Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. Int J Mol Med. 2005 Oct;16(4):717-22.
11 Human cytochrome P450 1A1 is a novel target gene of liver X receptor alpha. Drug Metab Pharmacokinet. 2011;26(5):451-7.