Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYZFXN)

• Drug Name: Lornoxicam Drug Info
• Synonyms: CTX; Chlortenoxicam; Lorcam; Safem; Telos; Xefo; Xefo Rapid; HN-10000; TS-110; Ro-13-9297

Indication

Disease Entry	ICD 11	Status	REF
Migraine	8A80	Approved	[1]

• Cross-matching ID:
  PubChem CID: 54690031
  ChEBI ID: CHEBI:31783
  CAS Number: CAS 70374-39-9
  TTD Drug ID: DMYZFXN
  INTEDE Drug ID: DR0981

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin G/H synthase (COX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[5]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[6]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Dexibuprofen	DMFYBD0	Ankylosing spondylitis	FA92.0	Approved	[8]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[9]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[10]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[11]
Aceclofenac	DMZDF0B	Inflammation	1A00-CA43.1	Approved	[12]
Morniflumate	DM9UTDE	Otitis media	AA80-AB0Z	Approved	[13]
Nepafenac	DMYK490	Osteoarthritis	FA00-FA05	Approved	[14]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[15]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[18]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[20]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[21]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[30]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[32]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[33]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[34]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[35]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[37]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[38]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase (COX)	TTK0943	PGH1_HUMAN; PGH2_HUMAN	Modulator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9) Main DME	DE5IED8	CP2C9_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Gene/Protein Processing	[4]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Gene/Protein Processing	[4]

References

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