General Information of Drug (ID: DMZDFRI)

Drug Name
Acanthus ilicifolius Linn Drug Info
Synonyms
AC1L1B2B; CBiol_001885; KBioGR_000483; KBioSS_000483; BSPBio_001143; (-)-Huperzine A-d5 (Major); CHEMBL3184073; KBio3_000886; CTK8E6796; KBio2_003051; BDBM10441; KBio2_005619; KBio2_000483; KBio3_000885; Bio2_000402; Bio1_001149; Bio1_000660; HMS1990I05; Bio2_000882; Bio1_000171; AKOS032962044; AN-1052; KS-0000000G; IDI1_002157; NCGC00163246-01; FT-0642946; N1881; Acarviostatin III03; Acarviostatin IV03
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
1253
CAS Number
CAS 102518-79-6
TTD Drug ID
DMZDFRI

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [3]
Diethylcarbamazine DM1TJ8F Elephantiasis Approved [4]
Silymarin DMXBYQR N. A. N. A. Phase 4 [5]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [6]
Avastin+/-Tarceva DMA86FL Non-small-cell lung cancer 2C25.Y Phase 3 [7]
ABT-761 DM3FIC2 Asthma CA23 Phase 3 [8]
Tenidap DMHQRYE Rheumatoid arthritis FA20 Phase 3 [9]
FPL-62064 DMGF8MZ Inflammation 1A00-CA43.1 Phase 3 [10]
Flobufen DMPSG4D Rheumatoid arthritis FA20 Phase 3 [11]
Darbufelone DMYVKM5 Asthma CA23 Phase 2/3 [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pancrecarb DMOML9Q Pancreatic malfunction DC30-DC3Z NDA filed [13]
Liprotamase DMNF4UH Cystic fibrosis CA25 Phase 3 [14]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [15]
Pyroglutamic Acid DMROZUA Discovery agent N.A. Investigative [15]
6-Deoxy-Alpha-D-Glucose DM9HBY5 Discovery agent N.A. Investigative [15]
Acarbose Derived Hexasaccharide DMS9COH Discovery agent N.A. Investigative [15]
Maltosyl-Alpha (1,4)-D-Gluconhydroximo-1,5-Lactam DMMY542 Discovery agent N.A. Investigative [16]
Hydroxycitric acid DMY0A9E Discovery agent N.A. Investigative [17]
Alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen DM4IXUQ Discovery agent N.A. Investigative [18]
Alpha-acarviosinyl-(1-->7)-3-alpha-D-glucopyranosylpropen DMHV14R Discovery agent N.A. Investigative [18]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 5-lipoxygenase (5-LOX) TT2J34L LOX5_HUMAN Inhibitor [1]
Pancreatic alpha-amylase (AMY2A) TTCGSZ4 AMYP_HUMAN Inhibitor [2]

References

1 Anti-inflammatory activity of Acanthus ilicifolius. J Ethnopharmacol. 2008 Oct 30;120(1):7-12.
2 Four acarviosin-containing oligosaccharides identified from Streptomyces coelicoflavus ZG0656 are potent inhibitors of alpha-amylase. Carbohydr Res. 2008 Apr 7;343(5):882-92.
3 5-lipoxygenase inhibitor zileuton attenuates ischemic brain damage: involvement of matrix metalloproteinase 9. Neurol Res. 2009 Oct;31(8):848-52.
4 Inhibition of leukotriene formation by diethylcarbamazine modifies the acid-base balance in the rabbits with blast injuries of the lungs. Vojnosanit Pregl. 1999 May-Jun;56(3):243-7.
5 Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000 Mar;7(1):21-4.
6 Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity. Neurosci Lett. 2008 Nov 7;445(1):1-6.
7 Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity. J Med Chem. 1997 Nov 7;40(23):3773-80.
8 Treatment with 5-lipoxygenase inhibitor VIA-2291 (Atreleuton) in patients with recent acute coronary syndrome. Circ Cardiovasc Imaging. 2010 May;3(3):298-307.
9 The in vitro free radical scavenging activity of tenidap, a new dual cyclo-oxygenase and 5-1ipoxygenase inhibitor. Mediators Inflamm. 1992;1(2):141-3.
10 FPL 62064, a topically active 5-lipoxygenase/cyclooxygenase inhibitor. Agents Actions. 1990 Jun;30(3-4):432-42.
11 Pharmacological profile of the novel potent antirheumatic 4-(2',4'-difluorobiphenyl-4-yl)-2-methyl-4-oxobutanoic acid. Arzneimittelforschung. 1997 May;47(5):648-52.
12 Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. Bioorg Med Chem. 2013 May 1;21(9):2551-9.
13 Clinical pipeline report, company report or official report of Digestive Care.
14 Clinical pipeline report, company report or official report of Anthera Pharmaceuticals.
15 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
16 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
17 Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol. 2007 Jul;75(5):977-82.
18 Enzymatic synthesis of a selective inhibitor for alpha-glucosidases: alpha-acarviosinyl-(1-->9)-3-alpha-D-glucopyranosylpropen. J Agric Food Chem. 2008 Jul 9;56(13):5324-30.