Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZL48U)

Drug Name

KUR-111 Drug Info

Synonyms

I-0401; I-040302; TGplPTH1-34; Fibrin-PTH (bone cysts), Kuros; Human parathyroid hormone (PTH) + TISSEEL fibrin sealant + hydroxyapatite/tri-calcium phosphate granules (bone fracture), Kuros/Baxter

Indication

Disease Entry	ICD 11	Status	REF
Bone disease	FC0Z	Phase 2	[1]

Cross-matching ID

TTD Drug ID: DMZL48U

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Parathyroid hormone (PTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teriparatide	DMMC45B	Exostosis		Approved	[3]
Ostabolin-C	DMBVI6E	Osteoporosis	FB83.0	Phase 2	[4]
ABX-PTH	DMDPUK6	Parathyroid disease	5A50-5A5Z	Terminated	[5]
SUN-E3001	DMAM3OH	Osteoporosis	FB83.0	Terminated	[6]
MG-1101	DM710KZ	Discovery agent	N.A.	Investigative	[7]
parathyroid hormone	DMKJY3U	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Parathyroid hormone (PTH)	TT6F7GZ	PTHY_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT00459641) Safety and Tolerability of I-040302 in Children and Young Adults With Solitary Bone Cysts. U.S. National Institutes of Health.
2	Company report (Cytos)
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	ZT-031, a cyclized analog of parathyroid hormone(1-31) for the potential treatment of osteoporosis. IDrugs. 2008 Nov;11(11):827-40.
5	Focus on parathyroid carcinoma. International Journal of Surgery Volume 9, Issue 1, 2011, Pages 13-19.
6	Effects of teriparatide [recombinant human parathyroid hormone (1-34)] on cortical bone in postmenopausal women with osteoporosis. J Bone Miner Res. 2003 Mar;18(3):539-43.
7	Daily parathyroid hormone 1-34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure.J Bone Miner Res.2012 Aug;27(8):1811-20.