Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZLJRS)

Drug Name

5-fluoro-6-azido-UMP Drug Info

Synonyms

uridine derivative, 41; CHEMBL514166; SCHEMBL15189843; BDBM27944; {[(2R,3S,4R,5R)-5-(6-azido-5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16666489
TTD Drug ID: DMZLJRS

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Orotidine 5'-monophosphate decarboxylase (UMPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha-Phosphoribosylpyrophosphoric Acid	DMT6KI7	Discovery agent	N.A.	Investigative	[2]
6-Hydroxyuridine-5'-Phosphate	DMDMNQV	Discovery agent	N.A.	Investigative	[3]
Pyrazofurin	DMVJLSM	Discovery agent	N.A.	Investigative	[4]
5-fluoro-6-amino-UMP	DM6QHIA	Discovery agent	N.A.	Investigative	[1]
5-fluoro-6-iodo-UMP	DM3LMIS	Discovery agent	N.A.	Investigative	[1]
5-Fluoro-6-ethyluridine-5'-O-monophosphate	DMTAZ71	Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Orotidine 5'-monophosphate decarboxylase (UMPS)	TTAFJUD	UMPS_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J Med Chem. 2009 Mar 26;52(6):1648-58.
2	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
4	Molecular approaches for the treatment of hemorrhagic fever virus infections. Antiviral Res. 1993 Sep;22(1):45-75.