Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZU1GD)

Drug Name

1,5-Dideoxy-1,5-imino-D-xylitol Drug Info

Synonyms

PIPERIDINE-3,4,5-TRIOL; (3R,4r,5S)-piperidine-3,4,5-triol; CHEMBL110830; 13042-55-2; 1,5-dideoxy-1,5-imino-xylitol; XYLOSE-DERIVED 1-DEOXY-NOJIRIMYCIN; XDN; dideoxyiminoxylitol; 1,5-Dideoxy-1,5-imino-D-xylitol; AC1L9IA9; SCHEMBL955713; SCHEMBL2435095; SCHEMBL2435099; 1,5-dideoxy-1,5-iminoxylitol; MolPort-042-605-431; 172588-13-5; 3alpha,4beta,5alpha-Piperidinetriol; FCH951710; 3alpha,4alpha,5alpha-Piperidinetriol; BDBM50182798; (3S,5R)-piperidine-3,4,5-triol; AKOS006351347; ZINC104595290; ZINC100872034; AKOS006294154

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 445612
TTD Drug ID: DMZU1GD

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glucosylceramidase (GBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Velaglucerase alfa	DM4BOAS	Gaucher disease type I		Approved	[2]
Taliglucerase alfa	DM3PZXN	Metabolic disorder	5C50-5D2Z	Approved	[3]
Isofagomine tartrate	DM2RS0V	Metabolic disorder	5C50-5D2Z	Phase 2	[4]
Afegostat	DMRWSKX	Gaucher disease	5C56.0Y	Discontinued in Phase 2	[5]
NCGC607	DMXG0O1	Gaucher disease	5C56.0Y	Preclinical	[6]
N-Octyl-beta-valienamine	DM39C47	Gaucher disease	5C56.0Y	Preclinical	[7]
2-(Acetylamino)-2-Deoxy-a-D-Glucopyranose	DMOUG6Y	Discovery agent	N.A.	Investigative	[8]
L-Isofagomine	DM6RKOC	Discovery agent	N.A.	Investigative	[1]
(2R,3S,4S,5R)-2-propylpiperidine-3,4,5-triol	DM7GI94	Discovery agent	N.A.	Investigative	[9]
N-(Propylamide-acetophenone)-1-deoxynojirimycin	DMXI4V8	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucosylceramidase (GBA)	TT1B5PU	GLCM_HUMAN	Inhibitor	[1]

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References

1	In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorg Med Chem. 2008 Aug 1;16(15):7330-6.
2	Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
3	Nat Rev Drug Discov. 2013 Feb;12(2):87-90.
4	Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. Chembiochem. 2008 Nov 3;9(16):2650-62.
5	Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.
6	A New Glucocerebrosidase Chaperone Reduces alpha-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism. J Neurosci. 2016 Jul 13;36(28):7441-52.
7	Chemical modification of the beta-glucocerebrosidase inhibitor N-octyl-beta-valienamine: synthesis and biological evaluation of 4-epimeric and 4-O-(beta-D-galactopyranosyl) derivatives. Bioorg Med Chem. 2002 Jun;10(6):1967-72.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
9	Synthesis of new beta-1-C-alkylated imino-L-iditols: A comparative study of their activity as beta-glucocerebrosidase inhibitors. Bioorg Med Chem. 2010 Apr 1;18(7):2645-50.
10	Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorg Med Chem. 2010 Jan 1;18(1):267-73.