Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZY41U)

Drug Name

Para-Isopropylaniline Drug Info

Synonyms

4-ISOPROPYLANILINE; 99-88-7; Cumidine; 4-Aminocumene; p-Isopropylaniline; p-Cumidine; 4-(Propan-2-Yl)Aniline; 4-Amino-1-isopropylbenzene; PARA-ISOPROPYLANILINE; Cumene, p-amino-; Aniline, p-isopropyl-; Benzenamine, 4-(1-methylethyl)-; Cumidene; UNII-0D54T7V7XL; 4-propan-2-ylaniline; 4-(2-propyl)aniline; NSC 7198; 4-Isopropylaniline, 99%; 0D54T7V7XL; .beta.-(4-Aminophenyl)propane; LRTFPLFDLJYEKT-UHFFFAOYSA-N; 4-(methylethyl)phenylamine; ss-(4-Aminophenyl)Propane; Iso; 4-(1-methylethyl)aniline; cumidin; beta-(4-Aminophenyl)propane

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 7464
ChEBI ID: CHEBI:43405
CAS Number: CAS 99-88-7
TTD Drug ID: DMZY41U

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Pancreatic elastase 1 (CELA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[2]
Erdosteine	DM6QFSV	Bronchitis	CA20	Approved	[3]
Sivelestat	DM6BZCV	Crohn disease	DD70	Phase 3	[4]
Mdl 101,146	DMRSOBG	Inflammation	1A00-CA43.1	Terminated	[1]
WIN-63759	DMRV48P	Emphysema	CA21	Terminated	[5]
SSR-69071	DMWL4MI	Chronic obstructive pulmonary disease	CA22	Terminated	[6]
SYN-1134	DMG2SQM	Cystic fibrosis	CA25	Terminated	[7]
PBI-1101	DMWD1RC	Inflammation	1A00-CA43.1	Terminated	[8]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[1]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pancreatic elastase 1 (CELA1)	TT3NKIB	CELA1_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	Elastase inhibitors. J Soc Biol. 2001;195(2):143-50.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4	Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome... Shock. 2010 Jan;33(1):14-8.
5	Biological activity of WIN 63759, an orally bioavailable inhibitor of human neutrophil elastase. Drug Development Research Volume 34, Issue 3, pages 306-316, March 1995.
6	Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem. 2011 Aug 19;286(33):28889-901.
7	EP patent application no. 1292314, Method for treating respiratory disorders associated with pulmonary elastic fiber injury comprising the use of glycosaminoglycans.
8	CN patent application no. 1813706, Use of elastic protease inhibitor for preparing medicine for protecting cerebral hemorrhage.
9	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.