Details of the Drug Pharmacogenomic Perturbation Atlas

General Information of Drug (ID: DM065ZH)

Drug Name
CCT-018159 Drug Info
Synonyms
CCT 018159; CCT018159; (6Z)-6-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1,2-dihydropyrazol-3-ylidene]-4-ethyl-3-hydroxycyclohexa-2,4-dien-1-one; 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl]-6-ethylbenzene-1,3-diol
Therapeutic ClassAnticancer Agents
Cross-matching ID
PubChem CID
984170
ChEBI ID
CHEMBL399530
CAS Number
CAS 171009-07-7
TTD Drug ID
D00OCB

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)
Term Name NES FDR q-val Tag % Leading Edge Genes
Antigen processing and presentation 2.15 0.00e+0 60/78 (76.92%) HSPA1A;HSPA8;HSPA6;...
Ribosome 2.02 0.00e+0 113/158 (71.52%) RPS27L;MRPL18;RPL35A;...
Longevity regulating pathway 1.94 6.75e-3 90/151 (59.6%) HSPA1A;HSPA8;HSPA6;...
Protein processing in endoplasmic reticulum 1.91 5.06e-3 127/171 (74.27%) HSPA1A;HSPA8;HSPH1;...
Spliceosome 1.82 1.35e-2 101/150 (67.33%) HSPA1A;HSPA8;HSPA6;...
Glycine, serine and threonine metabolism 1.79 1.35e-2 31/40 (77.5%) PSAT1;CBS;CTH;...
Arginine biosynthesis 1.75 2.22e-2 17/22 (77.27%) ARG2;GLS2;GLUL;...
Ribosome biogenesis in eukaryotes -1.75 4.62e-2 52/108 (48.15%) BMS1;RAN;NHP2;...
Cell cycle -1.81 2.73e-2 110/124 (88.71%) CCNB1;E2F1;PRKDC;...
Base excision repair -1.83 2.12e-2 29/33 (87.88%) NEIL1;OGG1;POLD1;...
Rheumatoid arthritis -1.92 7.64e-3 78/93 (83.87%) CD28;ATP6V1H;ATP6V1B2;...
PPAR signaling pathway -1.92 9.55e-3 66/74 (89.19%) DBI;ACADM;PLIN1;...
IL-17 signaling pathway -2.06 0.00e+0 84/94 (89.36%) MAPK1;CASP3;MAPK9;...
DNA replication -2.20 0.00e+0 34/36 (94.44%) RFC5;POLA2;POLD1;...
Steroid biosynthesis -2.21 0.00e+0 19/20 (95%) NSDHL;TM7SF2;DHCR24;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Bone
Osteosarcoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
U-2 OS CVCL_0042 Homo sapiens 10uM 6H
Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 10uM 6H, 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 10uM 6H
Hematopoietic system
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
ASC CVCL_U602 Homo sapiens 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 10uM 6H, 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
1HAEo- CVCL_0128 Homo sapiens 10uM 24H
NL20 CVCL_0461 Homo sapiens 10uM 24H
Liver
Hepatoblastoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Hep G2 CVCL_0027 Homo sapiens 10uM 6H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 10uM 6H, 24H
Non-small cell lung carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HCC515 CVCL_5134 Homo sapiens 10uM 6H, 24H
Normal (Fibroblast)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HFL1 CVCL_4295 Homo sapiens 10uM 24H
IMR-90 CVCL_0347 Homo sapiens 10uM 24H
WI-38 CVCL_0579 Homo sapiens 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 1.11uM - 10uM 6H, 24H
VCaP CVCL_2235 Homo sapiens 10uM 6H, 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 1.11uM - 10uM 6H, 24H