General Information of Drug (ID: DM0798Z)

Drug Name
NLG8189 Drug Info
Synonyms
1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189
Cross-matching ID
PubChem CID
405012
ChEBI ID
CHEMBL571209
CAS Number
CAS 110117-83-4
TTD Drug ID
D0B5HS

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name NES FDR q-val Tag % Leading Edge Genes
Proteasome 1.79 1.76e-1 44/46 (95.65%) PSMB5;PSMC3;PSMC4;...
Thiamine metabolism 1.72 1.60e-1 12/15 (80%) TPK1;AK2;ALPL;...
Circadian rhythm 1.71 1.12e-1 26/31 (83.87%) PER2;PRKAA1;PER3;...
Spliceosome 1.63 1.76e-1 101/150 (67.33%) HSPA1A;HSPA8;SNU13;...
DNA replication 1.60 2.10e-1 34/36 (94.44%) RFC5;MCM6;MCM5;...
Propanoate metabolism 1.58 2.02e-1 30/34 (88.24%) PCCB;SUCLG2;ACAT1;...
Parkinson disease 1.57 1.88e-1 176/249 (70.68%) DAXX;PSMB5;UCHL1;...
Alanine, aspartate and glutamate metabolism 1.56 1.89e-1 27/37 (72.97%) GLUD2;ASNS;GLS2;...
Sulfur relay system 1.54 1.99e-1 5/8 (62.5%) TST;MOCS2
Amino sugar and nucleotide sugar metabolism 1.52 2.14e-1 38/48 (79.17%) UAP1;GMDS;UGP2;...
Proximal tubule bicarbonate reclamation 1.52 1.95e-1 21/23 (91.3%) CA2;ATP1A1;GLUD2;...
Malaria 1.50 2.10e-1 44/50 (88%) TLR4;COMP;TLR2;...
Amyotrophic lateral sclerosis 1.48 2.36e-1 267/364 (73.35%) DAXX;SEH1L;GPX7;...
Staphylococcus aureus infection 1.42 3.33e-1 72/95 (75.79%) KRT19;KRT17;KRT15;...
Arginine biosynthesis 1.35 4.43e-1 17/22 (77.27%) GLUD2;GLS2;GLUL;...
Protein export 1.33 4.48e-1 17/23 (73.91%) OXA1L;SRP54;SRP14;...
Starch and sucrose metabolism 1.33 4.35e-1 25/36 (69.44%) UGP2;GBA3;GYG2;...
Protein processing in endoplasmic reticulum 1.33 4.16e-1 127/171 (74.27%) DAD1;HSPH1;HSPA1A;...
Linoleic acid metabolism 1.31 4.34e-1 21/29 (72.41%) PLAAT3;PLA2G4C;CYP2C9;...
Neutrophil extracellular trap formation 1.31 4.22e-1 101/189 (53.44%) HAT1;TLR4;TLR2;...
Prion disease 1.31 4.08e-1 209/273 (76.56%) PSMB5;ATP5MC2;COX7A1;...
Transcriptional misregulation in cancer 1.30 4.09e-1 158/192 (82.29%) LMO2;MLF1;ERG;...
Basal transcription factors 1.30 3.95e-1 37/45 (82.22%) GTF2E1;TAF5;TAF10;...
Type II diabetes mellitus 1.29 4.15e-1 42/46 (91.3%) IRS2;INSR;CACNA1A;...
Retinol metabolism 1.29 4.22e-1 41/68 (60.29%) ALDH1A3;CYP26B1;DHRS9;...
Cysteine and methionine metabolism 1.27 4.44e-1 43/50 (86%) CBS;TST;BCAT1;...
Pathways of neurodegeneration 1.27 4.37e-1 354/475 (74.53%) DAXX;GPX7;PSMB5;...
Mismatch repair 1.27 4.28e-1 22/23 (95.65%) RFC5;MSH2;MLH1;...
Nitrogen metabolism 1.27 4.23e-1 16/17 (94.12%) CA2;GLUD2;GLUL;...
Bile secretion 1.26 4.37e-1 68/90 (75.56%) CA2;ATP1A1;UGT2B15;...
Human cytomegalovirus infection -1.32 4.33e-1 201/225 (89.33%) GNG10;RPS6KB1;CDKN1A;...
JAK-STAT signaling pathway -1.33 4.39e-1 146/162 (90.12%) IL5;IL5RA;PIK3R2;...
Arrhythmogenic right ventricular cardiomyopathy -1.33 4.48e-1 70/77 (90.91%) SGCG;ACTB;LAMA2;...
Yersinia infection -1.34 4.45e-1 120/137 (87.59%) ZAP70;MEFV;GNAQ;...
Human papillomavirus infection -1.34 4.56e-1 284/331 (85.8%) PPP2R5D;PTEN;RPS6KB1;...
TNF signaling pathway -1.36 4.13e-1 103/112 (91.96%) PIK3CD;TRAF2;TNFRSF1A;...
Autoimmune thyroid disease -1.36 4.23e-1 46/53 (86.79%) HLA-DMB;IFNA4;CTLA4;...
Non-small cell lung cancer -1.36 4.39e-1 70/72 (97.22%) CDKN1A;RXRA;GADD45G;...
Prostate cancer -1.37 4.53e-1 93/97 (95.88%) PLAU;PIK3CD;CCND1;...
Breast cancer -1.38 4.46e-1 119/147 (80.95%) FGF9;DVL2;PTEN;...
Dilated cardiomyopathy -1.39 4.49e-1 86/96 (89.58%) SLC8A1;ADCY1;SGCG;...
Intestinal immune network for IgA production -1.42 3.60e-1 38/48 (79.17%) CCR9;HLA-DMB;IL5;...
Endometrial cancer -1.43 3.59e-1 56/58 (96.55%) MAP2K2;PIK3R2;BAD;...
NOD-like receptor signaling pathway -1.43 3.80e-1 145/181 (80.11%) BIRC2;MEFV;TNFAIP3;...
Rheumatoid arthritis -1.43 4.00e-1 78/93 (83.87%) MMP3;IL18;ITGB2;...
Shigellosis -1.45 3.72e-1 180/246 (73.17%) RRAGA;CBX3;FOXO4;...
Vibrio cholerae infection -1.46 3.58e-1 44/50 (88%) PRKACA;ATP6V1F;CFTR;...
Thyroid hormone signaling pathway -1.46 3.75e-1 112/121 (92.56%) RXRA;PFKM;ATP1A2;...
GnRH secretion -1.47 3.71e-1 60/64 (93.75%) PIK3CD;PLCB4;GABBR2;...
Kaposi sarcoma-associated herpesvirus infection -1.48 3.88e-1 172/193 (89.12%) CDKN1A;IRF9;HLA-G;...
Amoebiasis -1.50 3.51e-1 99/102 (97.06%) IL12A;GNAQ;CD1E;...
Relaxin signaling pathway -1.50 3.83e-1 114/129 (88.37%) PIK3CD;MMP1;PLCB4;...
Glycerolipid metabolism -1.55 2.83e-1 44/61 (72.13%) DGKG;AGPAT1;AGPAT2;...
Apoptosis -1.57 2.83e-1 126/168 (75%) BCL2A1;TP53AIP1;GADD45G;...
Prolactin signaling pathway -1.57 3.14e-1 66/70 (94.29%) PIK3CD;CCND1;GRB2;...
Steroid biosynthesis -1.61 2.67e-1 19/20 (95%) SOAT1;CYP51A1;CYP24A1;...
ECM-receptor interaction -1.63 2.64e-1 80/88 (90.91%) LAMC3;CD47;COL6A3;...
Other glycan degradation -1.63 3.44e-1 13/18 (72.22%) HEXB;MANBA;MAN2C1;...
Lysosome -1.72 2.05e-1 115/128 (89.84%) CTSO;M6PR;PSAP;...
Small cell lung cancer -1.82 1.29e-1 90/92 (97.83%) BIRC2;PTEN;CDKN1A;...
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Pharmacogenomic Perturbation Across Diseases and Tissues

Breast
Breast adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF7 CVCL_0031 Homo sapiens 0.01uM - 10uM 24H
MDA-MB-231 CVCL_0062 Homo sapiens 0.01uM - 10uM 24H
Breast epithelium
Normal
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
MCF-10A CVCL_0598 Homo sapiens 0.01uM - 10uM 24H
Cervix
Cervical adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HeLa CVCL_0030 Homo sapiens 0.01uM - 10uM 24H
Colon
Colorectal adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HT-29 CVCL_0320 Homo sapiens 0.01uM - 10uM 24H
Kidney
Normal (Immortalized)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HA1E CVCL_0284 Homo sapiens 0.01uM - 10uM 24H
Normal (Transformed)
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
HEK293 CVCL_0045 Homo sapiens 0.01uM - 10uM 24H
Lung
Lung adenocarcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A549 CVCL_0023 Homo sapiens 0.01uM - 10uM 24H
Pancreas
Pancreatic carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
YAPC CVCL_1791 Homo sapiens 0.01uM - 10uM 24H
Peripheral blood
Acute monocytic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
THP-1 CVCL_0006 Homo sapiens 0.01uM - 10uM 24H
T-cell acute lymphoblastic leukemia
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
Jurkat CVCL_0367 Homo sapiens 0.01uM - 10uM 24H
Prostate
Prostate carcinoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
PC-3 CVCL_0035 Homo sapiens 0.01uM - 10uM 24H
Skin
Melanoma
Cell Line Name Cellosaurus Accession Species of Origin Drug Dosage Time Point Details
A-375 CVCL_0132 Homo sapiens 0.01uM - 10uM 24H