Details of the Drug

General Information of Drug (ID: DM0798Z)

Drug Name

NLG8189

Synonyms

1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Phase 2/3	[1]
Pancreatic cancer	2C10	Phase 2	[1]
Prostate cancer	2C82.0	Phase 2	[1]
Acute myeloid leukaemia	2A60	Phase 1	[1]
Brain cancer	2A00	Phase 1	[1]

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

218.25

Logarithm of the Partition Coefficient (xlogp)

-1.3

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

Chemical Identifiers

Formula: C12H14N2O2
IUPAC Name: (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid
Canonical SMILES: CN1C=C(C2=CC=CC=C21)C[C@H](C(=O)O)N
InChI: InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1
InChIKey: ZADWXFSZEAPBJS-SNVBAGLBSA-N