Details of the Drug Pharmacogenomic Perturbation Atlas | DrugMAP

General Information of Drug (ID: DM0B7NO)

Drug Name	Isoarnebin 4 Drug Info
Synonyms	Shikonin; NSC 252844; Shikonin S; Shikonin,(S); Tokyo Violet
Therapeutic Class	Antiviral Agents
Cross-matching ID	PubChem CID 479503 ChEBI ID CHEMBL9470 CAS Number CAS 517-89-5 TTD Drug ID D0QM4U

Consensus Signature of Drug Pharmacogenomic Perturbation (DPP)

Term Name	NES	FDR q-val	Tag %	Leading Edge Genes
Pentose and glucuronate interconversions	2.05	0.00e+0	17/34 (50%)	UGT2B17;UGT2B28;AKR1B10;...
Retinol metabolism	1.99	0.00e+0	41/68 (60.29%)	UGT2B17;UGT2B28;CYP26B1;...
Base excision repair	1.91	8.98e-3	29/33 (87.88%)	POLE2;SMUG1;NTHL1;...
Ascorbate and aldarate metabolism	1.80	2.69e-2	15/30 (50%)	UGT2B17;UGT2B28;ALDH2;...
Autoimmune thyroid disease	-1.72	4.53e-2	46/53 (86.79%)	CD80;CD86;HLA-DRB1;...
Type I diabetes mellitus	-1.74	4.40e-2	38/43 (88.37%)	CD80;CD86;HLA-DRB1;...
Graft-versus-host disease	-1.78	4.21e-2	32/42 (76.19%)	IL1B;CD80;CD86;...
Complement and coagulation cascades	-1.79	3.08e-2	76/85 (89.41%)	C5;C4BPB;VWF;...
Rheumatoid arthritis	-1.87	2.20e-2	78/93 (83.87%)	CTSL;FLT1;CD80;...
Vibrio cholerae infection	-1.88	2.93e-2	44/50 (88%)	ADCY3;ATP6V0D1;ATP6V0C;...
Phagosome	-1.88	4.40e-2	118/152 (77.63%)	HLA-DRB1;ATP6V0D1;ATP6V0C;...
Phenylalanine metabolism	-1.94	2.20e-2	14/17 (82.35%)	MAOA;DDC;AOC3;...

Pharmacogenomic Perturbation Across Diseases and Tissues

Liver

Hepatocellular carcinoma

Cell Line Name	Cellosaurus Accession	Species of Origin	Drug Dosage	Time Point	Details
HuH-7	CVCL_0336	Homo sapiens	12uM	72H